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Mammalian Phospholipase D and Related Activities

  • J. N. Kanfer
  • H. Hattori
Part of the NATO ASI Series book series (NSSA, volume 116)

Abstract

Phospholipase D activity has been detected in all mammalian membranes analyzed (1). This capacity to hydrolyze lecithin yielding choline and phosphatide acid is particularly active in synaptic membranes prepared from rat brain. The properties of the synaptic enzyme, its potential role in acetylcholine formation, its reduction in Alzheimer’s disease and potential involvement in phosphatidylethanol formation in the Fetal Alcohol syndrome will be presented.

Keywords

Oleic Acid Phosphatide Acid Fetal Alcohol Syndrome Sodium Oleate Synaptic Membrane 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Chalifour, R.J. and Kanfer, J.N. (1980) Biochem. Biophys. Res. Commun. 96: 742–747.PubMedCrossRefGoogle Scholar
  2. 2.
    Cotman, C.W. (1974) Methods in Enzymology 31: 445–452.PubMedCrossRefGoogle Scholar
  3. 3.
    Ueda, T., Greengard, P., Berzins, K., Cohen, R.S., Bloomberg, F., Grab, D.W. and Siekevitz, P.J. (1979) J. Cell Biol. 83: 308–319.PubMedCrossRefGoogle Scholar
  4. 4.
    Chalifour, R. and Kanfer, J.N. (1982) J. Neurochem. 39: 299–305.PubMedCrossRefGoogle Scholar
  5. 5.
    Diamond, I. and Kennedy, E.P. (1968) Anal. Biochem. 24: 90–95.PubMedCrossRefGoogle Scholar
  6. 6.
    Satomi, D. (1983) J. Biochem. 94: 785–791.PubMedGoogle Scholar
  7. 7.
    Kanfer, J.N. (1982) Biochem. Biophys. Res. Commun. 106: 422–428.CrossRefGoogle Scholar
  8. 8.
    Hall, W.Z. (1973) J. Neurobiol. 4: 343–361.PubMedCrossRefGoogle Scholar
  9. 9.
    Kanoh, H. and Ohno, K. (1981) Methods in Enzymology, Vol. 71, p. 536–545, (ed. by J.M. Lowenstein).Google Scholar
  10. 10.
    Butler, M. and Morell, P. (1983) J. Neurochem. 41: 1445–1454.PubMedCrossRefGoogle Scholar
  11. 11.
    Wallick, E.T., Dowd, S., Allen, J.C. and Schwartz, A. (1974) J. Pharmacol. Exp. Ther. 189: 434–444.PubMedGoogle Scholar
  12. 12.
    Hattori, H., Bansal, V.S., Orihel, D. and Kanfer, J.N. (1984) J. Neurochem. 43: 1018–1024.PubMedCrossRefGoogle Scholar
  13. 13.
    Folch, J., Lees, M. and Sloane-Stanley, G.H. (1957) J. Biol. Chem. 226: 497–509.PubMedGoogle Scholar
  14. 14.
    Chang, Ta-Chuang Lo and Sweeley, C.C. (1963) Biochemistry 2: 592–604.CrossRefGoogle Scholar
  15. 15.
    Sweeley, C.C. (1967) Methods Enzymol. 14: 254–267.CrossRefGoogle Scholar
  16. 16.
    Bartlett, G.R. (1959) J. Biol. Chem. 234: 466–468.PubMedGoogle Scholar
  17. 17.
    Chalifour, R.J. and Kanfer, J.N. (1982) J. Neurochem. 39: 299–305.PubMedCrossRefGoogle Scholar
  18. 18.
    Bowen, D.M., Spillone, J.A., Curzon, G., Neier-Ruge, W., White, P., Goodhardt, M.J., Iwangoff, P. and Davidson, A.N. (1979) Lancet 1: 11–14.PubMedGoogle Scholar
  19. 19.
    Wurtman, R. (1985) Sci. American 252: 48–56CrossRefGoogle Scholar
  20. 20.
    Woelk, H. and Porcellati, G. (1973) Hoppe Seylers Z. Physiol. Chem. 354: 90–100.PubMedCrossRefGoogle Scholar
  21. 21.
    Gershon, Z.L. and Gatt, S. (1976) Biochem. Biophys. Res. Commun. 69: 592–598.CrossRefGoogle Scholar
  22. 22.
    Ansell, G.B. and Spanner, S. (1979) in Nutrition and Brain, Vol. 5 (Barbeau, A., Growdon, J.H. and Wurtman, R.J., eds.), pp. 35–46. Raven Press, New York.Google Scholar
  23. 23.
    Blusztajn, J.K. and Wurtman, R.J. (1981) Nature 290: 417–418.PubMedCrossRefGoogle Scholar
  24. 24.
    Witter, B. and Kanfer, J.N. (1985) J. Neuroehem. 44: 155–162.CrossRefGoogle Scholar
  25. 25.
    MacIntosh, F.C. and Collier, B. (1976) Handbook of Experimental Pharmacology 42: 99–228.Google Scholar
  26. 26.
    Yang, S.F., Freer, S. and Benson, A.A. (1967) J. Biol. Chem. 242: 477–484.PubMedGoogle Scholar
  27. 27.
    Dawson, R.M.C. (1967) Biochem. J. 102: 205–210.PubMedGoogle Scholar
  28. 28.
    Chalifour, R.J., Taki, T. and Kanfer, J.N. (1980) Can. J. Biochem. 48: 1189–1196.Google Scholar
  29. 29.
    Ailing, C., Gustaysson, L. and Anggard, E. (1983) FEBS. Lett. 152: 24–28.CrossRefGoogle Scholar
  30. 30.
    Ailing, C., Gustaysson, L., Mansson, J-E., Benthin, G. and Anggard, E. (1984) Biochim. Biophys. Acta 793: 119–122.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • J. N. Kanfer
    • 1
  • H. Hattori
    • 1
  1. 1.Department of Biochemistry Faculty of MedicineUniversity of ManitobaWinnipegCanada

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