Regulatory Properties of Carnitine Palmitoyltransferase in the Mitochondrial Membrane of Liver
Fritz (1955) reported that carnitine stimulated the oxidation of fatty acids in liver homogenates. This phenomenon has subsequently been explained by a transport of activated fatty acids in the form of acylcarnitines through the inner mitochondrial membrane (Bremer 1962, Fritz and Yue 1963). This transport links the activation of fatty acids in the outer membrane of the mitochondria (and in the endoplasmatic reticulum) to the β-oxidation of activated fatty acids in the mitochondrial matrix (Norum et. al. 1966, Skrede and Bremer 1970, Yates and Garland 1970).
KeywordsLiver Mitochondrion Carnitine Palmitoyltransferase Intact Mitochondrion Carnitine Acyltransferases Mitochondrial Carnitine
Unable to display preview. Download preview PDF.
- Bergseth, S., Lund, H., and Bremer, J., 1985, Carnitine palmitoyltransferase. Activation and inactivation in liver mitochondria from fed, fasted, hypo-and hyperthyroid rats. To be published.Google Scholar
- Christiansen,R.Z., Christophersen, B.O., and Bremer, J., 1977, Monoethylenic C2p and C fatty acids in marine oil and rapeseed oil. Studies on their oxidation and their relative ability to inhibit palmitate oxidation in heart and liver mitochondria. Biochim. Biophys. Acta, 487: 28.PubMedCrossRefGoogle Scholar
- Fritz, I.B., 1955. The effects of muscle extracts on the oxidation of palmitic acid by liver slices and homogenates. Acta Physiol. Chem., 34: 367.Google Scholar
- McGarry, J.D., Mills, S.E., Long, C.S., and Foster, D.W., 1983, Observations on the affinity for carnitine, and malonyl-CoA sensitivity, of carnitine palmitoyltransferase I in animal and human tissues. Biochem. J., 214–21.Google Scholar
- Woldegiorgis, G., Bremer, J., and Shrago, E., 1985, Carnitine palmitoyltransferase: Substrate inhibition by palmitoyl-CoA and activation by phospholipids and proteins. Biochim. Biophys. Acta, in press.Google Scholar