Regulatory Properties of Carnitine Palmitoyltransferase in the Mitochondrial Membrane of Liver

  • Jon Bremer
  • Steinar Bergseth
  • Henrik Lund
Part of the NATO ASI Series book series (NSSA, volume 116)


Fritz (1955) reported that carnitine stimulated the oxidation of fatty acids in liver homogenates. This phenomenon has subsequently been explained by a transport of activated fatty acids in the form of acylcarnitines through the inner mitochondrial membrane (Bremer 1962, Fritz and Yue 1963). This transport links the activation of fatty acids in the outer membrane of the mitochondria (and in the endoplasmatic reticulum) to the β-oxidation of activated fatty acids in the mitochondrial matrix (Norum et. al. 1966, Skrede and Bremer 1970, Yates and Garland 1970).


Liver Mitochondrion Carnitine Palmitoyltransferase Intact Mitochondrion Carnitine Acyltransferases Mitochondrial Carnitine 
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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Jon Bremer
    • 1
  • Steinar Bergseth
    • 1
  • Henrik Lund
    • 1
  1. 1.Institute of Medical BiochemistryUniversity of OsloBlindern, Oslo 3Norway

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