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Nuclear Triiodothyronine Receptors and Mechanisms of Triiodothyronine and Insulin Action on the Synthesis of Cerebroside Sulfotransferase by Cultures of Cells Dissociated from Brains of Embryonic Mice

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Enzymes of Lipid Metabolism II

Part of the book series: NATO ASI Series ((NSSA,volume 116))

Abstract

Many studies have shown that the CNS is markedly dependent on thyroid hormones for its overall growth and its biochemical and morphological development (1–6). Indeed, thyroid hormone deficiency at birth, if not recognized and corrected at an early stage, results in irreversible brain damage such as: impaired growth nerve cell processes resulting in a decrease in the number of neuronal contacts, increased cell death, reduced myelination and severe mental retardation (6–16). Significantly, these defects are amenable to hormone therapy only during an early critical age period (6). In contrast, in the hyperthyroid state, myelin synthesis commences and terminates earlier (17).

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Abbreviations

CNS:

central nervous system

PAPS:

3′-phosphoadenosine-5′-phosphosulfate

CST:

cerebroside sulfotransferase

T3:

L-3,5,3′-triiodothyronine

DIV:

days in vitro

DIC:

days in culture

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Authors and Affiliations

  1. Departamento de Bioquimica, Faculdade de Ciencias Médicas, Universidade Nova, 1198, Lisboa Codex, Portugal

    Véronique Ferret-Sena & Armando Sena

  2. Centre de Neurochimie du CNRS & U.44 de l’INSERM, 5 rue B. Pascal, 67084, Strasbourg Cedex, France

    Gérard Rebel, Louis Freysz, Guy Vincendon & Louis Sarliève

  3. Departamento de Endocrinologia Experimental, Instituto Investigaciones Biomedicas, C.S.I.C., Facultad de Medicina de la Universidad Autonoma de Madrid, 28029, Madrid, Spain

    Angel Pascual

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  1. Véronique Ferret-Sena
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  3. Gérard Rebel
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  4. Angel Pascual
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  5. Louis Freysz
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  1. CNRS Center for Neurochemistry and INSERM U44, Louis Pasteur University, Strasbourg, France

    Louis Freysz , Henri Dreyfus  & Raphaël Massarelli ,  & 

  2. Hebrew University-Hadassah School of Medicine, Jerusalem, Israel

    Shimon Gatt

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Ferret-Sena, V. et al. (1986). Nuclear Triiodothyronine Receptors and Mechanisms of Triiodothyronine and Insulin Action on the Synthesis of Cerebroside Sulfotransferase by Cultures of Cells Dissociated from Brains of Embryonic Mice. In: Freysz, L., Dreyfus, H., Massarelli, R., Gatt, S. (eds) Enzymes of Lipid Metabolism II. NATO ASI Series, vol 116. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5212-9_74

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