HMGR (3-Hydroxy, 3-Methylglutaryl-CoA Reductase) Activity of Cultured Rat Brain Cells: Sensitivity to n-3 and n-6 Polyunsaturated Fatty Acids (PUFAs) from Cod-Liver and Sunflower Oils

  • J. Raulin
  • D. Lapous
  • C. Loriette
  • I. K. Grundt
Part of the NATO ASI Series book series (NSSA, volume 116)


It is currently assumed that 14C-acetate incorporation into sterols, and HMGR activity are similar from fetal life to new-born and adult ages. However, both the cholesterol synthesis and the HMGR activity show changing patterns, growing in fetal life, very low at birth and rising after weaning — likely responding to regulation of cholesterol synthesis in mammary gland (Gibbons and Pullinger, 1983). Cholesterol and mevalonate are very active in the regulation of HMGR, but regulation is not noticeable before birth (Leoni et al., 1985) — at least, in the freshly isolated hepatocytes. Other cellular constituents may have regulatory action (Grinstead et al,, 1983), phenomenon already described as per various tissues.


Oleic Acid Brain Cell Cholesterol Synthesis Fetal Life MEVALONIC Acid 
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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • J. Raulin
    • 1
  • D. Lapous
    • 1
  • C. Loriette
    • 1
  • I. K. Grundt
    • 2
  1. 1.Biologie Cellulaire, Groupe NutritionUniversité Paris 7Paris 05France
  2. 2.Clinical BiochemistryUniversity of BergenHaukelandNorway

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