A Model for Studying Membrane Fatty Acid Transport : Acyl-Coenzyme a Synthesis in Human Erythrocyte Ghosts
The mechanism by which unesterified fatty acids are translocated across plasma membranes remains unclear and is the object of several experimental approaches. This translocation process is essential to the cell physiology, especially in organs such as heart, muscle and kidney which derive mostly their energy from the oxidation of fatty acids (Gold and Spitzer, 1964; Fritz, 1961; Neely and Morgan, 1974). Most cells undergo de novo synthesis of acyl chains. However, all tissues take up preformed long chain saturated, monounsaturated and polyunsaturated fatty acids. Metabolic utilization including activation, esterification and oxidation pathways follows fatty acid uptake and membrane translocation which are discussed hereby.
KeywordsPalmitic Acid Fatty Acid Uptake Fatty Acid Concentration Translocation Process Fatty Acid Molecule
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