The Asymmetrical Distribution and Biosynthesis of Molecular Species of Phospholipids in Chick Brain Microsomes

  • A. Erhardt
  • F. Golly
  • L. Binaglia
  • C. Leray
  • R. Massarelli
  • L. Freysz
Part of the NATO ASI Series book series (NSSA, volume 116)


Phospholipids are found in all cellular membranes. In the nervous system, they constitute a very heterogenous class of compounds containing a large amount of various molecular species, which do not only differ in the nature of their polar head but also in the structure of their fatty acids (1). This observation arises a general question: why do membranes of the nervous system contain so many molecular species of phospholipids and does each molecular species play a specific role in the functional activity of nerve cells ? The physicochemical properties and biological activities of nerve membranes depend in part on their phospholipid composition (2), hence several studies have been focused on the fatty acid distribution of the phospholipids in different cellular and subcellular fractions (3–4). These investigations have shown that the different cell membranes of the nervous systems have phospholipid composition and fatty acid distribution which are characteristic for each membrane, suggesting the requirement of specific molecular species of phospholipids for the various functional properties of the membranes.


Fatty Acid Composition Molecular Species Phospholipid Composition Outer Leaflet Fatty Acid Distribution 







Trinitrobenzene sulfonic acid.


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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • A. Erhardt
    • 1
  • F. Golly
    • 1
  • L. Binaglia
    • 1
    • 2
  • C. Leray
    • 1
  • R. Massarelli
    • 1
  • L. Freysz
    • 1
  1. 1.Centre de Neurochimie du CNRS and U44 de l’INSERMStrasbourg CedexFrance
  2. 2.Department of Biochemistry The Medical SchoolUniversity of PerugiaPerugiaItaly

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