The Asymmetrical Distribution and Biosynthesis of Molecular Species of Phospholipids in Chick Brain Microsomes
Phospholipids are found in all cellular membranes. In the nervous system, they constitute a very heterogenous class of compounds containing a large amount of various molecular species, which do not only differ in the nature of their polar head but also in the structure of their fatty acids (1). This observation arises a general question: why do membranes of the nervous system contain so many molecular species of phospholipids and does each molecular species play a specific role in the functional activity of nerve cells ? The physicochemical properties and biological activities of nerve membranes depend in part on their phospholipid composition (2), hence several studies have been focused on the fatty acid distribution of the phospholipids in different cellular and subcellular fractions (3–4). These investigations have shown that the different cell membranes of the nervous systems have phospholipid composition and fatty acid distribution which are characteristic for each membrane, suggesting the requirement of specific molecular species of phospholipids for the various functional properties of the membranes.
KeywordsFatty Acid Composition Molecular Species Phospholipid Composition Outer Leaflet Fatty Acid Distribution
Trinitrobenzene sulfonic acid.
Unable to display preview. Download preview PDF.
- 1.G. Porcellati and G. Arienti, Metabolism of phosphoglycerides, in: “Handbook of Neurochemistry”, A. Lajtha, ed., Plenum Press, New York (1983), pp. 133–161.Google Scholar
- 2.A.A. Farooqui and L.A. Horrocks, Metabolic and functional aspects of neural membrane phospholipids, in: “Phospholipids in the Nervous System, Vol. 2 Physiological Roles”, L.A. Horrocks, J.N. Kanfer and G. Porcellati, eds., Raven Press, New York (1985), pp. 341–348.Google Scholar
- 3.D.A. White, The phospholipid composition of mammalian tissues, in: “Form and Function of Phospholipids”, G.B. Ansell, J.N. Hawthorne and R.M.C. Dawson, eds., Elsevier, Amsterdam (1973), PP. 441-482.Google Scholar
- 10.G.B. Ansell, Phospholipids and the nervous system, in: “Form and Function of Phospholipids”, G.B. Ansell, J..N. Hawthorm and R.M.C. Dawson, eds., Elsevier, Amsterdam (1973), PP. 377–422.Google Scholar
- 14.E.E. Hill and E.M. Lands, Phospholipid metabolism, in: “Lipid Metabolism”, S.J. Wakil, ed., Academic Press, New York (1970), PP. 185–277.Google Scholar
- 17.L. Freysz, L. Binaglia, J. Dominski and G. Porcellati, Topological biosynthesis of phospholipids in brain microsomes, in: “Phospholipids in the Nervous System, Vol. 2 Physiological Roles”, L.A. Horrocks, J.N. Kanfer and G. Porcellati, eds., Raven Press, New York (1985), pp. 279–288.Google Scholar
- 23.R.M. Bell, B.R. Ganong and R. Bishop, Phospholipid bilayer assembly: facilitated transmembrane movement of phosphatidylcholine, this hook, pp. 407–413.Google Scholar
- 24.X. Pelletier, G. Duportail and C. Leray, Isolation and characterization of Brush-Border membrane from trout intestine. Regional differences, Biochim. Biophys. Acta (1986) in press.Google Scholar