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Biosynthesis of Gangliosides and Blood Group Glycolipids Using Solubilized Glycosyltransferases

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Enzymes of Lipid Metabolism II

Part of the book series: NATO ASI Series ((NSSA,volume 116))

Abstract

Since the discovery of GM2 ganglioside (GalNAcß l-4(NeuAcα2–3)Galßl­4Glc-Cer) from Tay-Sachs brains by Klenk,l at least 50 different structures of sialic acid- and fucose-containing glycosphingolipids(GSLs)2–7have been described. There is increasing evidence that GSLs are involved in the interaction of cholera toxin,8 plant lectins,9,10 interferon,11 siga toxin,12 and polypeptide hormones13 with receptor sites at the surfaces of plasma membranes.

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Authors and Affiliations

  1. Department of Chemistry Biochemistry, Biophysics and Molecular Biology Program, University of Notre Dame, Notre Dame, Indiana, 46556, USA

    Subhash Basu, Tripti De, John W. Kyle, Kamal K. Das & Robert J. Schaeper

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  1. Subhash Basu
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  2. Manju Basu
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  3. Tripti De
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  4. John W. Kyle
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Editors and Affiliations

  1. CNRS Center for Neurochemistry and INSERM U44, Louis Pasteur University, Strasbourg, France

    Louis Freysz , Henri Dreyfus  & Raphaël Massarelli ,  & 

  2. Hebrew University-Hadassah School of Medicine, Jerusalem, Israel

    Shimon Gatt

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© 1986 Plenum Press, New York

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Basu, S., Basu, M., De, T., Kyle, J.W., Das, K.K., Schaeper, R.J. (1986). Biosynthesis of Gangliosides and Blood Group Glycolipids Using Solubilized Glycosyltransferases. In: Freysz, L., Dreyfus, H., Massarelli, R., Gatt, S. (eds) Enzymes of Lipid Metabolism II. NATO ASI Series, vol 116. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5212-9_33

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  • DOI: https://doi.org/10.1007/978-1-4684-5212-9_33

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5214-3

  • Online ISBN: 978-1-4684-5212-9

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