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The Peroxisomal Enzymes of Glycerolipid Metabolism

  • A. K. Hajra
  • M. K. Ghosh
  • K. O. Webber
  • N. S. Datta
Part of the NATO ASI Series book series (NSSA, volume 116)

Abstract

Acyl dihydroxyacetone phosphate (acyl DHAP1) is known to be an important precursor of glycerolipids, especially of glycerol ether lipids (1–5). Acyl DHAP was first characterized as a lipid rapidly labeled with [γ-32P]ATP in guinea pig liver mitochondrial fractions (6,7). This rapid labeling was due to the consecutive actions of a phosphohydrolase (Reaction 1, Fig. 1) and a kinase (Reaction 2, Fig. 1) on the endogenous acyl DHAP (8). Later, it was shown that this lipid is biosynthesized by the enzymatic acylation of DHAP with long-chain acyl CoA’s (Reaction 3, Fig. 1) (9,10). Acyl DHAP, thus formed, could be reduced by NADPH to 1-acyl-sn-glycerol-3-phosphate (1-acyl GP1) (Reaction 4, Fig. 1) which is the precursor of all glycerides and phosphoglycerides (11). 1-Acyl GP is also biosynthesized by a direct acylation of GP (Reaction 7, Fig. 1) (3,4).

Keywords

Ether Lipid Dihydroxyacetone Phosphate Peroxisomal Membrane Peroxisomal Enzyme Refsum Disease 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Hajra, A.K. (1977) Biochem. Soc. Trans. 5, 34–36.PubMedGoogle Scholar
  2. 2.
    Hajra, A.K. (1983) In Ether Lipids (Mangold, H.K. & Paltauf, F., Ed.) pp. 83–106, Academic Press, New York.Google Scholar
  3. 3.
    Van den Bosch, H. (1974) Annu. Rev. Biochem. 43, 243–277.PubMedCrossRefGoogle Scholar
  4. 4.
    Bell, R.M. and Coleman, R.A. (1980) Annu. Rev. Biochem. 49, 459–587.PubMedCrossRefGoogle Scholar
  5. 5.
    Wykle, R.L. and Snyder, F. (1976) In The Enzymes of Biological Membranes (J.A. Martonosi, Ed.) vol. 2, pp. 87–117, Plenum Press, New York.CrossRefGoogle Scholar
  6. 6.
    Hajra, A.K. and Agranoff, B.W. (1967) J. Biol. Chem. 242, 1074–1075PubMedGoogle Scholar
  7. 7.
    Hajra, A.K. and Agranoff, B.W. (1968) J. Biol. Chem. 243, 3542–3543.PubMedGoogle Scholar
  8. 8.
    Hajra, A.K., Seguin, E.B. and Agranoff, B.W. (1968) J. Biol. Chem. 243, 1609–1616.PubMedGoogle Scholar
  9. 9.
    Hajra, A.K. (1968) J. Biol. Chem. 243, 3458–3465.PubMedGoogle Scholar
  10. 10.
    LaBelle, E.F., Jr. and Hajra, A.K. (1972) J. Biol. Chem. 247, 5825–5834.PubMedGoogle Scholar
  11. 11.
    LaBelle, E.F., Jr. and Hajra, A.K. (1972) J. Biol. Chem. 247, 5835–5841.PubMedGoogle Scholar
  12. 12.
    Hajra A. K. (1970) Biochem. Biophys. Res. Commun. 39, 1037–1043.PubMedCrossRefGoogle Scholar
  13. 13.
    Bishop, J.E. and Hajra, A.K. (1981) J. Biol. Chem. 256, 9542–9550.PubMedGoogle Scholar
  14. 14.
    LaBelle, E.F., Jr. and Hajra, A.K. (1974) J. Biol. Chem. 249, 6936–6944.PubMedGoogle Scholar
  15. 15.
    Paltauf, F. (1978) In Enzymes of Lipid Metabolism (S. Gatt, L. Freysz and P. Mandel, Eds.), pp. 387–345, Plenum Press, New York.CrossRefGoogle Scholar
  16. 16.
    Friedberg, S.J. and Heifetz, A. (1973) Biochemistry 12, 1100–1106.PubMedCrossRefGoogle Scholar
  17. 17.
    Opperdoes, F.R. (1984) FEBS Lett. 169, 35–39PubMedCrossRefGoogle Scholar
  18. 18.
    Van den Bosch, H. and Vagelos, P.R. (1970) Biochim. Biophys. Acta 218, 233–238CrossRefGoogle Scholar
  19. 19.
    Gurr, M.I. (1980) In The Biochemistry of Plants, Vol. 4, Lipids (P.K. Stumpf, Ed.), p. 240, Academic Press, New York.Google Scholar
  20. 20.
    Schlossman, D.M. and Bell, R.M. (1978) J. Bact. 133, 1368–1376.PubMedGoogle Scholar
  21. 21.
    Mullick, P.C. and Hajra, A.K. (1982) Fed. Proc. 41, 2325.Google Scholar
  22. 22.
    Manning, R. and Brindley, D.N. (1972) Biochem. J. 140, 249–251.Google Scholar
  23. 23.
    Rognstad, F.R., Clark, D.G. and Katz, J. (1974) Biochem. J. 140, 249–251.PubMedGoogle Scholar
  24. 24.
    Pollock, R.J., Hajra, A.K. and Agranoff, B.W. (1976) J. Biol. Chem. 251, 5149–5154.PubMedGoogle Scholar
  25. 25.
    Groener, J.E.M. and Van Golde, L.M.G. (1977) Biochim. Biophys. Acta 710, 15–22.Google Scholar
  26. 26.
    Mason, R.J. (1978) J. Biol. Chem. 253, 3367–3370PubMedGoogle Scholar
  27. 27.
    Schlossman, D.M. and Bell, R.M. (1977) Arch. Biochem. Biophys. 172, 732–742.CrossRefGoogle Scholar
  28. 28.
    Coleman, R.A. and Bell, R.M. (1983) The Enzymes 16, 87–111.CrossRefGoogle Scholar
  29. 29.
    Jones, C.L. and Hajra, A.K. (1980) J. Biol. Chem. 255, 8289–8295PubMedGoogle Scholar
  30. 30.
    Fisher, A.B., Huber, G.A., Furia, L., Basset, D. and Rabinowitz, J.L. (1976) J. Lab & Clin. Med. 87, 1033–1040.Google Scholar
  31. 31.
    Bates, E.J. and Saggerson, E.D. (1979) Biochem. J. 182, 751–762.PubMedGoogle Scholar
  32. 32.
    Declercq, P.E., Haagsman, H.P., Veldhoven, P.A., Debeer, L.J., VanGolde, L.M.G. and Mannaerts, G. (1984) J. Biol. Chem. 259, 9064–9075.PubMedGoogle Scholar
  33. 33.
    Datta, N.S. and Hajra, A.K. (1984) FEBS Lett. 176, 264–268.PubMedCrossRefGoogle Scholar
  34. 34.
    Friedberg, S.J., Heifetz, A. and Greene, R.C. (1971) J. Biol. Chem. 246, 5822–5827.PubMedGoogle Scholar
  35. 35.
    Friedberg, S.J. and Heifetz, A. (1975) Biochemistry 14, 570–574.PubMedCrossRefGoogle Scholar
  36. 36.
    Friedberg, S.J., Gomillion, D.M. and Stotter, P.L. (1980) J. Biol. Chem. 255, 1074–1079.PubMedGoogle Scholar
  37. 37.
    Davis, P.A. and Hajra, A.K. (1979) J. Biol. Chem. 254, 4760–4763.PubMedGoogle Scholar
  38. 38.
    Davis, P.A. and Hajra, A.K. (1977) Biochem. Biophys. Res. Commun. 74, 100–105.CrossRefGoogle Scholar
  39. 39.
    Davis, P.A. and Hajra, A.K. (1981) Arch. Biochem. Biophys. 211, 20–29.PubMedCrossRefGoogle Scholar
  40. 40.
    Brown, A.J. and Snyder, F. (1982) J. Biol. Chem. 257, 8835–8839.PubMedGoogle Scholar
  41. 41.
    Brown, A.J. and Snyder, F. (1983) J. Biol. Chem. 258, 4184–4189.PubMedGoogle Scholar
  42. 42.
    Jones, C.L. and Hajra, A.K. (1983) Arch. Biochem. Biophys. 226, 155–165.PubMedCrossRefGoogle Scholar
  43. 43.
    Hajra, A.K. and Burke, C.L. (1978) J. Neurochem. 31, 125–134.PubMedCrossRefGoogle Scholar
  44. 44.
    Hajra, A.K., Datta, N. and Salem, M. (1983) Fed. Proc. 42, 1864.Google Scholar
  45. 45.
    Jones, C.L. and Hajra, A.K. (1977) Biochem. Biophys. Res. Commun. 76, 1138–1143.PubMedCrossRefGoogle Scholar
  46. 46.
    Hajra, A.K., Burke, C.L. and Jones, C.L. (1979). J. Biol. Chem. 254, 10896–10900.PubMedGoogle Scholar
  47. 47.
    Hajra, A.K. and Bishop, J.E. (1982) Ann. N.Y. Acad. Sci. 386, 170–182.PubMedCrossRefGoogle Scholar
  48. 48.
    Hajra, A.K. and Wu, D. (1985) Anal. Biochem. 148, 233–244.PubMedCrossRefGoogle Scholar
  49. 49.
    Goldfischer, S., Moore, C.L., Johnson, A.B., Spiro, A.J., Valsamis, M.P., Wisniewskyk, H.K., Ritch, R.H., Norton, W.T., Rapin, I., Gartner, L.M. (1973) Science 182, 62–64.PubMedCrossRefGoogle Scholar
  50. 50.
    Moser, H.W. and Goldfischer, S.L. (1985) Hosp. Pract. 20, 61–70.Google Scholar
  51. 51.
    Goverts, L., Monnens, L., Tegelaers, W., Trijbels, F. and van RaaySelten, A. (1982) Eur. J. Ped. 139, 125–128.CrossRefGoogle Scholar
  52. 52.
    Borst, P. (1983) Trends Biochem. Sci. 8, 269–272.CrossRefGoogle Scholar
  53. 53.
    Heymans, H.S.A., Schutjens, R.B.H., Tan, R., Van den Bosch, H., Borst, P. (1983) Nature 306, 69–70.PubMedCrossRefGoogle Scholar
  54. 54.
    Lazarow, P.B., Black, V., Hajra, A.K., Datta, N.S., Bangaru, B., Dancis, J. (1984) Pediatr. Res. 18, 223a.CrossRefGoogle Scholar
  55. 55.
    Datta, N.S., Wilson, G.N. and Hajra, A.K. (1984) Fed. Proc. 43, 1653.Google Scholar
  56. 56.
    Datta, N.S., Wilson, G.N. and Hajra, A.K. (1984) New Eng. J. Med. 311, 1080–1083.PubMedCrossRefGoogle Scholar
  57. 57.
    Schutjens, R.B.H., Romeyn, G.J., Wanders, R.J.A., Van den Bosch, H., Schrakamp, G., Heymans, H.S.A. (1984) Biochem. Biophys. Res. Commun. 120, 179–184.CrossRefGoogle Scholar
  58. 58.
    Hajra, A.K., Datta, N.S., Jackson, G.L., Moser, A.B., Moser, H.W., Larsen, J.W. and Powers, J. (1985) New Eng. J. Med. 312, 445–446.PubMedCrossRefGoogle Scholar
  59. 59.
    Schrakamp, G., Rosenboom, C.F.P., Schutjens, R.B.H., Wanders, R.J.A., Heymans, H.S.A., Tager, J.M., Van den Bosch, H. (1985) J. Lipid Res. 26, 867–873.PubMedGoogle Scholar
  60. 60.
    Kelley, R.I., Datta, N.S., Dobyns, W.B., Hajra, A.K., Moser, A.B., Noetzel, J.M., Zackai, E.H. and Moser, H.W. (1985) Am. J. Med. Genetics (in press).Google Scholar
  61. 61.
    Poulos, A., Sharp, P. and Whiting M. (1984) Clin. Genet. 26, 579–586.PubMedCrossRefGoogle Scholar
  62. 62.
    Wanders, R.J.A., Kas, M., Roest, B., Meijer, A.J., Schrakamp, G., Heymans, H.S.A., Tegelaers, W.H.H., Van den Bosch, H., Schutjens, R.B.H., and Tager, J.M. (1984) Biochim. Biophys. Acta. 123, 1054–1061.Google Scholar
  63. 63.
    Tager, J.M., Van der Beck, T.H., Wanders, R.J.A., Hashimoto, T., Heymans, H.S.A., Van den Bosch, H., Schutjens, R.B.H. and Schram, A.W. (1985) Biochem. Biophys. Res. Commun. 126, 1269–1275.PubMedCrossRefGoogle Scholar
  64. 64.
    Heymans, H.S.A., Ooorthys, J.W.E., Nelck, G., Wanders, R.J.A. and Schutjens, R.B.H. (1985) New Eng. J. Med. 313, 187–188.PubMedGoogle Scholar
  65. 65.
    Bell, R.M., Ballas, L.M. and Coleman, R.A. (1981) J. Lipid Res. 22, 391–403.PubMedGoogle Scholar
  66. 66.
    Bishop, J.E., Salem, M. and Hajra, A.K. (1982) Ann. N.Y. Acad. Sci. 386, 411–413.CrossRefGoogle Scholar
  67. 67.
    deDuve, C. and Baudhin, P. (1966) Physiol. Rev. 46, 323–357.Google Scholar
  68. 68.
    Tolbert, N.E. (1981) Annu. Rev. Biochem. 50, 133–157.PubMedCrossRefGoogle Scholar
  69. 69.
    Masters, C. and Holmes, R. (1977) Physiol. Res. 57, 816–877.Google Scholar
  70. 70.
    Kindl, H. and Lazarow, P.B., Eds. (1982) Peroxisomes and Glyoxysomes, Ann. N.Y. Acad. Sci. Vol. 386.Google Scholar
  71. 71.
    Kimura, C., Kondo, A., Koeda, N., Yamanaka, H. and Mizugaki, M. (1984) J. Biochem. 96, 1463–1469.PubMedGoogle Scholar
  72. 72.
    Chu, C.H. and Schulz, H. (1985) FEBS Lett. 185, 129–134.PubMedCrossRefGoogle Scholar
  73. 73.
    Kase, F., Björkhem, I. and Pedersen, J.I. (1983) J. Lipid Res. 24, 1560–1567.PubMedGoogle Scholar
  74. 74.
    Keller, G.-A., Barton, M.C., Shapiro, D.J. and Singer, S.J. (1985) Proc. Natl. Acad Sci. 82, 770–774.PubMedCrossRefGoogle Scholar
  75. 75.
    Waechter, F., Bentley, P., Bieri, F., Stäubli, W., Völkl, A. and Fahimi, H.D. (1983) FEBS Lett. 158, 225–228.PubMedCrossRefGoogle Scholar
  76. 76.
    Osumi, T., Ishii, N., Hijikata, M., Kamijo, K., Ozasa, H., Furuta, S., Miyazawa, S., Kondo, K., Inoue, K., Kagamiyama, H. and Hashimoto, T. (1985) J. Biol. Chem. 260, 8905–8910PubMedGoogle Scholar
  77. 77.
    Lazarow, P.B. (1978) J. Biol. Chem. 253, 1522–1528.PubMedGoogle Scholar
  78. 78.
    Kondrup, J. and Lazarow, P.B. (1985) Biochim. Biophys. Acta 835, 147–153.PubMedCrossRefGoogle Scholar
  79. 79.
    Novikoff, A.B. and Novikoff, P.M. (1973) J. Histochem. and Cytochem. 21, 963–966.CrossRefGoogle Scholar
  80. 80.
    Novikoff, A.B., Novikoff, P.M., Rosen, O.M. and Rubin, C.S. (1980). J. Cell. Biol. 87, 180–196.PubMedCrossRefGoogle Scholar
  81. 81.
    Ballas, L.M., Lazarow, P.B. and Bell, R.M. (1984) Biochim. Biophys. Acta 795, 297–300.PubMedCrossRefGoogle Scholar
  82. 82.
    Opperdoes, F.R. and Borst, P. (1977) FEBS Lett. 80, 360–364.PubMedCrossRefGoogle Scholar
  83. 83.
    Pollock, R.J., Hajra, A.K. and Agranoff, B.W. (1975) Biochim. Biophys. Acta 380, 421–435.PubMedCrossRefGoogle Scholar
  84. 84.
    Murphy, P.A., Krahling, J.B., Gee, R., Kirk, J.R. and Tolbert, N.E. (1979) Arch. Biochem. Biophys. 193, 179–185.PubMedCrossRefGoogle Scholar
  85. 85.
    Das, A.K. and Hajra, A.K. (1984) Biochim. Biophys. Acta 796, 178–189.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • A. K. Hajra
    • 1
  • M. K. Ghosh
    • 1
  • K. O. Webber
    • 1
  • N. S. Datta
    • 1
  1. 1.Mental Health Research Inst. & Dept. of Biological ChemistryUniversity of MichiganAnn ArborUSA

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