Partial Characterization of the Cytosolic Phospholipase A1 of Rat Heart

  • Gilles Nalbone
  • Karl Y. Hostetler
  • Jeannie Leonardi
  • Huguette Lafont
Part of the NATO ASI Series book series (NSSA, volume 116)


In heart the maintenance of membrane integrity is essential for many cell functions including the need to control intracellular calcium concen­tration to ensure optimal inotropic conditions. In myocardial ischemia alterations in membrane phospholipids metabolism1–5 are thought to be of great importance since phospholipid degradation products, fatty acids and lysophospholipids, are potentially cytotoxic and may cause irregular heart rhythms6,7. The membrane phospholipids are subject to the action of intracel­lular phospholipases and lysophospholipases and detailed information about these enzymes are needed to allow a better understanding of membrane events in myocardial ischemia.


Membrane Phospholipid Cytosolic Phospholipase Recovered Activity Acylase Activity Irregular Heart Rhythms6 
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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Gilles Nalbone
    • 1
  • Karl Y. Hostetler
    • 1
    • 2
  • Jeannie Leonardi
    • 1
  • Huguette Lafont
    • 1
  1. 1.INSERM U-130MarseilleFrance
  2. 2.University of California and Veterans Administration HospitalLa JollaUSA

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