Partial Characterization of the Cytosolic Phospholipase A1 of Rat Heart
In heart the maintenance of membrane integrity is essential for many cell functions including the need to control intracellular calcium concentration to ensure optimal inotropic conditions. In myocardial ischemia alterations in membrane phospholipids metabolism1–5 are thought to be of great importance since phospholipid degradation products, fatty acids and lysophospholipids, are potentially cytotoxic and may cause irregular heart rhythms6,7. The membrane phospholipids are subject to the action of intracellular phospholipases and lysophospholipases and detailed information about these enzymes are needed to allow a better understanding of membrane events in myocardial ischemia.
KeywordsPermeability Hydrolysis Ischemia Lipase Thiol
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