Endogenous Suppression of Neutral-Active and Calcium-Dependent Phospholipase A2 Activity in Human Polymorphonuclear Leukocytes

  • Fritz Märki
  • Richard Franson
Part of the NATO ASI Series book series (NSSA, volume 116)


Neutral-active and calcium-dependent phospholipase A2 (PLA2) activity associated with cell granules and membranes has been observed previously in homogenates of human and rabbit polymorphonuclear leukocytes (PMNs)1–3. In these studies enzyme activity measured under similar assay conditions was more than ten times lower in the human than in the rabbit enzyme. We therefore investigated whether PLA2 activity of human PMN homogenates might be partly suppressed by an endogenous inhibitor.


Methyl Oleate Elaidic Acid Soluble Extract PLA2 Activity Resuspended Pellet 


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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Fritz Märki
    • 1
  • Richard Franson
    • 2
  1. 1.Research Department, Pharmaceuticals DivisionCiba-Geigy Ltd.BasleSwitzerland
  2. 2.Department of BiochemistryMedical College of VirginiaRichmondUSA

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