Monoacylglycerol Acyltransferase: Stereospecificity and Evidence that the Hepatic and Intestinal Activities are Tissue-Specific Isoenzymes
The transition from fetal to postnatal life is marked by dramatic changes in hepatic carbohydrate and lipid metabolism, as the supply of maternally-provided glucose ceases and the newborn becomes dependent on milk triacylglycerol for its energy and biosynthetic requirements. In perinatal rat liver, the enzyme activities involved in glycogen synthesis, gluconeogenesis, fatty acid oxidation and ketone body formation, rise whereas enzyme activities required for the synthesis of fatty acids decline (1–6).
KeywordsIntestinal Mucosa Fatty Acid Oxidation Postnatal Development Acyl Transferase Diacylglycerol Kinase
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- 1.P. Hahn, Nutrition and metabolic development in mammals, in “Nutrition: Pre-and Postnatal Development,” M. Winick, ed., Plenum Press, New York (1979).Google Scholar
- 10.R. A. Coleman and E. B. Haynes, Selective changes in microsomal enzymes of triacylglycerol and phosphatidylcholine synthesis in fetal and postnatal rat liver: Induction of microsomal sn-glycerol 3-phosphate and dihydroxyacetonephosphate acyltransferase activities, J. Biol. Chem. 258: 450 (1983).PubMedGoogle Scholar
- 18.R. A. Coleman, J. P. Walsh, D. S. Millington and D. A. Maltby, Stereospecificity of monoacylglycerol acyltransferase activity from rat intestine and suckling liver, submitted for publication.Google Scholar
- 19.R. A. Coleman and E. B. Haynes, Monoacylglycerol acyltransferase: Evidence that the activities from rat intestine and suckling liver are tissue-specific isoenzymes, J. Biol. Chem., in press (1986).Google Scholar
- 24.G. J. P. Fernando-Warnakulasuriya, J. E. Staggers, S. C. Frost and M. A. Wells, Studies on fat digestion, absorption, and transport in the suckling rat. 1. Fatty acid composition and concentrations of major lipid components, J. Lipid Res. 22: 668 (1984).Google Scholar