Modulation of Deacylation-Reacylation Pathway of Phospholipid Metabolism and Turnover During Reperfusion of Ischemic Myocardium

  • Dipak K. Das
Part of the NATO ASI Series book series (NSSA, volume 116)


The exact nature of injury associated with the reperfusion of ischemic myocardium is not yet clear, although current evidence suggests that maintenance of the membrane structural integrity is impaired when coronary blood flow is interrupted during ischemia [10]. The mechanisms of such injury are based on the degradation of phospholipids via phospholipases, which are stimulated by the influx of Ca++ as a consequence of the membrane alteration caused by ischemia [8]. However, short duration of ischemia of 10–30 min results in little or no loss of total membrane phospholipids. Prolonging the duration of ischemia to 3 hrs results in a 15% decrease in phospholipid concentrations [4]. Moreover, a brief period of ischemia followed by reperfusion activates lipases, stimulates accumulation of arachidonic acid, and enhances synthesis of prostaglandins [9]. Prostaglandin release is also observed during early reperfusion following 10 min occlusion of left anterior descending coronary artery [12].


Left Anterior Descend High Pressure Liquid Chromatography Microsomal Fraction Left Anterior Descend Occlusion Lysophosphatidylcholine Acyltransferase 


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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Dipak K. Das
    • 1
  1. 1.University of Connecticut School of MedicineFarmingtonUSA

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