Functional Adaptations of Transbilayer Proteins

  • Vincent T. Marchesi
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 205)


Many important functions commonly attributed to surface membranes are carried out by membrane-associated proteins that are tightly bound to the lipid bilayer. This class of proteins, which are engineered to extend completely across the lipid bilayer, sometimes in the form of multiple membrane-spanning loops, are generally referred to as transbilayer proteins. Most of the molecules that function as receptors for different proteins also modify cell functions by regulating the rates of transport of different substances across the lipid bilayer. Both types of proteins have unique structural features which allow them to interact with the lipid bilayer. One set of proteins, the receptor type, serve as conduits of information across the bilayer, while the other set, the channel proteins, selectively modify this barrier. This essay will present some generalizations about both types of transbilayer molecules that may help us to understand how they function in the environment of the intact cell.


Lipid Bilayer Amphipathic Helix Nonpolar Amino Acid Plasmodium Knowlesi Human Insulin Receptor 
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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Vincent T. Marchesi
    • 1
  1. 1.Department of PathologyYale University School of MedicineNew HavenUSA

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