Regulation of Na-Phosphate Cotransport in Cultured Renal Epithelial Cells: Protein-Synthesis-Dependent and Protein-Synthesis-Independent Pathways
The regulation of Na-phosphate cotransport across the apical membrane can, in analogy to classical enzymology, be divided into: short-term and long-term regulation. Short-term regulation involves: (i) allosteric and (ii) other activation-inactivation processes, e.g. covalent modifications such as phosphorylation or ADP-ribosylation. Long-term regulation usually involves de novo synthesis of the cotransporter. An additional regulatory mechanism can be considered for plasma membrane-bound systems: regulation via insertion or withdrawal of transporter from the membranes (endo-/exocytosis; for review see: Gmaj and Murer, 1985; Kempson and Dousa, 1985).
KeywordsBrush Border Membrane Phosphate Transport Phosphate Uptake Opossum Kidney Phosphate Deprivation
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