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Regulation of Na-Phosphate Cotransport in Cultured Renal Epithelial Cells: Protein-Synthesis-Dependent and Protein-Synthesis-Independent Pathways

  • Heini Murer
  • Jürg Biber
  • Kerstin Malmström
  • Ingvild Mohrmann
  • Michael Coady
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 208)

Abstract

The regulation of Na-phosphate cotransport across the apical membrane can, in analogy to classical enzymology, be divided into: short-term and long-term regulation. Short-term regulation involves: (i) allosteric and (ii) other activation-inactivation processes, e.g. covalent modifications such as phosphorylation or ADP-ribosylation. Long-term regulation usually involves de novo synthesis of the cotransporter. An additional regulatory mechanism can be considered for plasma membrane-bound systems: regulation via insertion or withdrawal of transporter from the membranes (endo-/exocytosis; for review see: Gmaj and Murer, 1985; Kempson and Dousa, 1985).

Keywords

Brush Border Membrane Phosphate Transport Phosphate Uptake Opossum Kidney Phosphate Deprivation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Heini Murer
    • 1
  • Jürg Biber
    • 1
  • Kerstin Malmström
    • 1
  • Ingvild Mohrmann
    • 1
  • Michael Coady
    • 1
  1. 1.Institute of PhysiologyUniversity of ZurichZurichSwitzerland

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