Regulation of Renal Na-K-ATPase: Effects of Aldosterone in Phosphate Depletion
Phosphate depletion is associated with multiple abnormalities in renal metabolism particularly the induction of depletion of intracellular adenine triphosphate nucleotides (ATP) (1–3). These nucleotides play a key role in renal transport since they are the substrates for multiple transport enzymes crucial to renal function, namely the transport ATPases: Na-K-ATPase, Ca-ATPase and H+-ATPase. Of these Na-K-ATPase consumes most of the energy required during renal transport operation and the activity of the enzyme is dependent on the intracellular level of the high energy nucleotide (4). Thus, a decrease in intracellular ATP, if critical, may lead to a reduction in the activity of the enzyme.
KeywordsPlasma Phosphate Phosphate Depletion Toad Bladder Urinary Potassium Excretion Weight Matched Control
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