Regulation of Renal Na-K-ATPase: Effects of Aldosterone in Phosphate Depletion

  • Salim K. Mujais
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 208)


Phosphate depletion is associated with multiple abnormalities in renal metabolism particularly the induction of depletion of intracellular adenine triphosphate nucleotides (ATP) (1–3). These nucleotides play a key role in renal transport since they are the substrates for multiple transport enzymes crucial to renal function, namely the transport ATPases: Na-K-ATPase, Ca-ATPase and H+-ATPase. Of these Na-K-ATPase consumes most of the energy required during renal transport operation and the activity of the enzyme is dependent on the intracellular level of the high energy nucleotide (4). Thus, a decrease in intracellular ATP, if critical, may lead to a reduction in the activity of the enzyme.


Plasma Phosphate Phosphate Depletion Toad Bladder Urinary Potassium Excretion Weight Matched Control 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    K. Kurokawa, Phosphate depletion and renal cell metabolism, in: “Nephrology,” R. R. Robinson, ed, Springer-Verlag, N.Y. (1984).Google Scholar
  2. 2.
    S. Sabatini, Clinical spectrum of phosphate depletion and its effects on urinary acidification, in: “Nephrology,” R. R. Robinson, ed, Springer-Verlag, N.Y. (1984).Google Scholar
  3. 3.
    Z. S. Agus and R. E. Garrick, Effect of phosphate depletion on renal tubular transport, in: “Nephrology,” R. R. Robinson, ed, Springer-Verlag, N.Y. (1984).Google Scholar
  4. 4.
    A. I. Katz, Renal Na-K-ATPase: Its role in tubular sodium and potassium transport. Am. J. Physiol. 242: F207 (1982).Google Scholar
  5. 5.
    S. K. Mujais, M. Chekal, W. J. Jones, J. P. Hayslett, and A. I. Katz, Regulation of renal Na-K-ATPase in the rat. Role of the natural mineralo-and glucocorticoid hormones. J. Clin. Invest. 73: 13 (1984).CrossRefGoogle Scholar
  6. 6.
    S. K. Mujais, M. A. Chekal, W. J. Jones, J. P. Hayslett, and A. I. Katz.. Modulation of renal Na-K-ATPase by aldosterone. Effect of high physiologic levels on enzyme activity in isolated rat and rabbit tubules. J Clin Invest 76: 170 (1985).CrossRefGoogle Scholar
  7. 7.
    N. Cortas,, E. Abras, and M. Walser. Aldosterone response in the turtle bladder is associated with an increase in ATP. Am. J. Physiol. 245: F512 (1983).Google Scholar
  8. 8.
    K. J. Petty, J. P. Kokko, and D. Marver, Secondary effect of aldosterone on Na-K-ATPase activity in the rabbit cortical collecting tubule. J Clin Invest 68: 1514 (1981).CrossRefGoogle Scholar
  9. 9.
    S. K. Mujais, M. A. Chekal, S.-M. K. Lee, and A. I. Katz, Relationship between adrenal steroids and renal Na-K-ATPase: Effect of short-term hormone administration on the rat cortical collecting tubule. Pflugers Archiv Eur J Physiol 402: 48 (1984).CrossRefGoogle Scholar
  10. 10.
    J. H. Hill, N. Cortas, and M. Walser, Aldosterone action and sodium-and potassium-activated adenosine triphosphatase in toad bladder. J Clin Invest 52: 185 (1973).CrossRefGoogle Scholar
  11. 11.
    K. Geering, M. Grardet, C. Bron, J. P. Kraehenbuhl, and B. C. Rossier, Hormonal regulation of (Na,K)-ATPase biosynthesis in the toad bladder: Effect of aldosterone and 3,5,3′-triiodo-l-thyronine. J Biol Chem 257: 10338 (1982).Google Scholar

Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Salim K. Mujais
    • 1
  1. 1.Department of MedicineNorthwestern University Medical SchoolChicagoUSA

Personalised recommendations