Factors Controlling the Intracellular Concentration of Orthophosphate (Pi) in Mammalian Cells

  • A. Bevington
  • G. J. Kemp
  • R. G. G. Russell
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 208)


It is ironic that while considerable effort and ingenuity have been expended over the past decade in measuring the low cytoplasmic concentrations of calcium (10−6 to 10−7 mole/1) in mammalian cells, relatively little attention has been paid to measurement of intracellular orthophosphate (Pi) (10−2 to 10−3 mole/1) and the factors controlling it. While it is commonly assumed that the biochemical basis for tissue damage during phosphate deprivation is a decrease in the intracellular concentration of Pi,1 there are a number of other important processes in which changes in intracellular concentrations of Pi have been implicated; notably regulation of anaerobic glycolysis,2 oxidative phosphorylation3 and basal metabolic rate;4 and modulation of calcium-activated cellular processes such as exocytosis.5


Organic Phosphate Ehrlich Ascites Tumor Cell Autologous Plasma Cytoplasmic Concentration Impaired Energy Metabolism 
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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • A. Bevington
    • 1
  • G. J. Kemp
    • 1
  • R. G. G. Russell
    • 1
  1. 1.Department of Human Metabolism & Clinical BiochemistryUniversity of Sheffield Medical SchoolSheffieldUK

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