Urine Citrate and Calcium in Calcium Nephrolithiasis

  • Joan H. Parks
  • Fredric L. Coe
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 208)


Our particular interest concerns urine citrate in idiopathic calcium oxalate stone disease. Only 3 previous (1,2,6) studies have included both sexes; they disagree as to the level of urine citrate, and the reduction of citrate in patients compared to normal, although both find that patients excrete less citrate than normals. They used different citrate methods. In one of the two, the numbers of women were small: 7 patients and 15 normals. In four other studies, of only men, patients were found to excrete between 97 and 63 percent as much citrate as normals (3,4,5,6,7).


Uric Acid Urine Calcium Calcium Oxalate Calcium Oxalate Stone Calcium Oxalate Monohydrate 
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  1. 1.
    Conway, N.S., Maitland, A.I.L., Rennie, J.B.: The urinary citrate excretion in patients with renal calculi. Br J Urol 21: 30–38, 1949.CrossRefGoogle Scholar
  2. 2.
    Hodgkinson, A.: Citric acid excretion in normal adults and in patients with renal calculus. Clin Sci 23: 203–212, 1962.Google Scholar
  3. 3.
    Robertson, W.G., Peacock, M., Nordin, B.E.C.: Activity products in stone-forming and non-stone-forming urine. Clin Sci 34: 579–594, 1968.Google Scholar
  4. 4.
    Elliot, J.S., Ribeiro, M.E.: The urinary excretion of citric, hippuric, and lactic acid in normal adults and in patients with calcium oxalate urinary calculus disease. Invest Urol 10: 102–106, 1972.Google Scholar
  5. 5.
    Welshman, S.G. and McGeown, M.G.: Urinary citrate excretion in stone-formers and normal controls. Br J Urol 48: 7–11, 1976.CrossRefGoogle Scholar
  6. 6.
    Schwille, P.O., Scholz, D., Paulus, M., Engelhardt, W., Sigel, A.: Citrate in daily and fasting urine; results of controls, patients with recurrent idiopathic calcium urolithiasis, and primary hyperparathyroidism. Invest Urol 16: 457–462, 1979.Google Scholar
  7. 7.
    Rudman, D., Kutner, M.H., Redd, S.C.II, Waters, W.C.IV, Gerron, G.G., Beier, J.: Hypocitraturia in calcium nephrolithiasis. J Clin Endo & Metab 55: 1052–1057, 1982.CrossRefGoogle Scholar
  8. 8.
    Walser, M.: Dissociation constants for complexes of citrate with sodium, potassium, calcium and magnesium ions. J Phys Chem 65: 159–169, 1961.CrossRefGoogle Scholar
  9. 9.
    Weber, D.V., Coe, F.L., Parks, J.H., and Tembe, V.: Urinary saturation measurements in calcium nephrolithiasis. Ann Int Med 90: 180–184, 1979.Google Scholar
  10. 10.
    Meyer, J.L., Smith L.H.: Growth of calcium oxalate crystals II. Inhibition by natural urinary crystal growth inhibitors. Invest Urol 13: 36–39, 1975.Google Scholar
  11. 11.
    Moellering H., Gruber W.: Determination of of citrate with citrate lyase. Anal Biochem 17: 369–376, 1966.CrossRefGoogle Scholar
  12. 12.
    Coe, F.L.: Uric acid and calcium oxalate nephrolithiasis. Kid Int 24: 392–403, 1983.CrossRefGoogle Scholar
  13. 13.
    Hodgkinson A., Williams A.: An improved colorimetric procedure for urine oxalate. Clin Chim Acta 36: 127–132, 1972.CrossRefGoogle Scholar
  14. 14.
    Pak, C.Y.C., Holt, K.: Nucleation and growth of brushite and calcium oxalate in urine of stone-formers. Metab 25: 665–673, 1976.CrossRefGoogle Scholar
  15. 15.
    Finlayson, B.: Calcium stones: some physical and clinical spects in calcium metabolism in renal failure and nephrolithiasis. D.S. Davis, ed., Wiley and Sons, New York, Ch 10, p 337–382, 1977.Google Scholar

Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Joan H. Parks
    • 1
  • Fredric L. Coe
    • 1
  1. 1.Renal ProgramUniversity of ChicagoChicagoUSA

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