Participation of Various Brain Nuclei in the Altered Time Course of Genetic Hypertension in SHR Dependent on Changes in Calcium Metabolism

  • H. Geiger
  • M. Palkovits
  • U. Bahner
  • G. Schmid
  • A. Heidland
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 208)


In recent theories concerning the pathogenesis of essential hypertension, abnormalities of calcium metabolism play an important part. The mechanisms involved in Ca-mediated blood pressure control are incompletely understood. An epidemiological survey of Kesteloot and Geboers in the Belgian army (1) showed a significant relationship between serum calcium, urinary calcium, and blood pressure in male participants. Results of animal studies demonstrated that restriction of calcium increases, and supplementation with calcium lowers the blood pressure of spontaneously hypertensive rats (2, 3, 4, 5). Based on the data of various studies made of the dietary calcium intake of normotensive and hypertensive individuals (6, 7, 8, 9, 10, 11) it is suggested that inadequate calcium consumption may be a previously unrecognized factor in the development of hypertension.


Locus Coeruleus Locus Coeruleus Neuron Serum Total Calcium Brain Nucleus Central Blood Pressure 
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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • H. Geiger
    • 1
  • M. Palkovits
    • 2
  • U. Bahner
    • 1
  • G. Schmid
    • 1
  • A. Heidland
    • 1
  1. 1.Medical Clinic of the University of WuerzburgWürzburgGermany
  2. 2.National Institute of Mental HealthBethesdaUSA

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