Disturbed Phosphate Metabolism in Spontaneously Hypertensive Rats

  • R. J. M. Bindels
  • C. H. van Os
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 208)


In spontaneously hypertensive rats (SHR) Ca2+ metabolism is abnormal when compared to normotensive Wistar-Kyoto rats (WKY). Disturbances in Ca2+ metabolism include a slight decrease in serum ionized Ca2+ concentration (McCarron et al., 1981; Wright and Rankin, 1982), hypercalciuria (McCarron et al., 1981; Bindels et al., 1984) and increased serum parathyroid hormone (PTH) levels (McCarron et al., 1981; Anderson et al., 1983). Finally, a high Ca2+ diet lowers the blood pressure in SHR (McCarron et al., 1981) after 18 weeks, proving the functional importance of the disturbed Ca2+ homeostasis in SHR.


Kidney Brush Border Membrane Increase Serum Parathyroid Hormone 


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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • R. J. M. Bindels
    • 1
  • C. H. van Os
    • 1
  1. 1.Department of PhysiologyUniversity of NijmegenNijmegenThe Netherlands

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