The Effect of Calcium on Renin, Aldosterone and Prostaglandin Release

  • J. L. Nadler
  • I. Antonipillai
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 208)


Evidence suggests that calcium (Ca2+) has an important regulatory role in the control of systemic and renal vascular tone. Acute and chronic hypercalcemia can increase blood pressure (Bp) and reduce renal blood flow (1–3). In contrast, pharmacologic blockade of Ca2+ entry into vascular smooth muscle can improve many forms of hypertension (4). The mechanisms of Ca2+ induced changes in vascular tone are complex since Ca2+ can directly produce vascular smooth muscle constriction or mediate the pressor actions of vasopressin, norepinephrine and angiotensin II (AII) (5,6). In addition, other studies reviewed in this paper indicate that Ca2+ may regulate Bp through important interactions with the renin-angiotensin and prostaglandin (PG) systems.


Renal Blood Flow Primary Aldosteronism Renin Release Zona Glomerulosa Renin Secretion 
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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • J. L. Nadler
    • 1
  • I. Antonipillai
    • 1
  1. 1.Section of EndocrinologyUniversity of Southern California Medical CenterLos AngelesUSA

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