Changes in Serum Calcium and Phosphorus Induced by Chronic Renal Failure in the Absence of Parathyroid Hormone
In the animal models of renal failure, despite the absence of parathyroid hormone (PTH), suppressed tubular reabsorption of phosphate is observed. Thus, processes independent of PTH result in enhancement of phosphate excretion even in chronic renal failure, as has been demonstrated in uremic parathyroidectomized dogs by Swenson et al (1).
KeywordsParathyroid Hormone Chronic Renal Failure Serum Calcium Fractional Excretion Tubular Reabsorption
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- 1.R.S. Swenson, J.R. Weisinger, J.L. Ruggeri, and G.M. Reaven, Evidence that Parathyroid Hormone is not Required for Phosphate Homeostasis in Renal Failure, Metabolism, 57: 264 (1976).Google Scholar
- 3.E. Kraus, G. Briefel, L. Cheng, B. Sacktor, and D. Spector, Phosphate Excretion in Uremic Rats: Effects of Parathyroidectomy and Phosphate Restriction, American Journal of Physiology, 248: F175 (abstract) (1985).Google Scholar
- 4.S.N. Tuma, and L.E. Mallette, Hypercalcemia after Nephrectomy in the Dog: Role of the Kidneys and Parathyroid Glands, Journal of Laboratory and Clinical Investigation, 102: 213 (1983).Google Scholar
- 6.F. Llach, S.G. Massry, F.R. Singer, K. Kurokawa, J.H. Kaye, and J.W. Coburn, Skeletal Resistance of Endogenous Parathyroid Hormone in Patients with Early Renal Failure: A Possible Cause of Secondary Hyperparathyroidism, Journal of Clinical Endocrinology and Metabolism, 41: 339–345 (1975).CrossRefGoogle Scholar
- 7.E.B. Newer, J. Backhouse, and C.M. Taylor, Failure of Formation of 1,25 Dihydroxycholecalciferol in Chronic Renal Insufficiency, Lancet 1: 626 (1973).Google Scholar
- 9.J.P. Bonjour and H. Fleisch, Calcium Supply and Renal Handling of Phosphate, Mineral and Electrolyte Metabolism 3: 261 (1980).Google Scholar