Mechanism of Nephrocalcinosis in Primary Hyperparathyroidism
Although nephrocalcinosis is a well-known complication of primary hyperparathyroidism, the mechanism by which calcium is deposited in the kidney is not understood. It is not known, for example, whether nephrocalcinosis is caused by hypercalcemia, hypophosphatemia or the product of calcium x phosphorus in plasma. In man it is not possible to regulate the independent variables that may be involved in the induction of nephrocalcinosis, and chronic animal models simulating primary hyperparathyroidism have not been developed. The present study was performed to examine the individual roles of Ca, P and the Ca x P product as causative factors in the induction of nephrocalcinosis, using an animal model of primary hyperparathyroidism in which each variable could be regulated by experimental design (1).
KeywordsPrimary Hyperparathyroidism Free Diet Osmotic Minipumps Soft Tissue Calcium Diphosphonic Acid
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