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Mechanism of Nephrocalcinosis in Primary Hyperparathyroidism

  • Ph. Jaeger
  • W. Jones
  • J. P. Hayslett
  • M. Kashgarian
  • G. V. Segre
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 208)

Abstract

Although nephrocalcinosis is a well-known complication of primary hyperparathyroidism, the mechanism by which calcium is deposited in the kidney is not understood. It is not known, for example, whether nephrocalcinosis is caused by hypercalcemia, hypophosphatemia or the product of calcium x phosphorus in plasma. In man it is not possible to regulate the independent variables that may be involved in the induction of nephrocalcinosis, and chronic animal models simulating primary hyperparathyroidism have not been developed. The present study was performed to examine the individual roles of Ca, P and the Ca x P product as causative factors in the induction of nephrocalcinosis, using an animal model of primary hyperparathyroidism in which each variable could be regulated by experimental design (1).

Keywords

Primary Hyperparathyroidism Free Diet Osmotic Minipumps Soft Tissue Calcium Diphosphonic Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Ph. Jaeger
    • 1
  • W. Jones
    • 1
  • J. P. Hayslett
    • 1
  • M. Kashgarian
    • 2
  • G. V. Segre
    • 3
  1. 1.Proctor and Gamble Co.CincinnatiUSA
  2. 2.Depts. of Int. Medicine and PathologyYale UniversityNew HavenUSA
  3. 3.Endocrine Unit, Massachusetts General HospitalHarvard UniversityBostonUSA

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