Determinants of Circulating Levels of 1.25(OH)2D3 (Calcitriol) in Primary Ry Hyperparathyroidism (PHPT)
The circulating level of 1,25(OH)2D3 (calcitriol) which controls intestinal absorption of calcium, has been suggested to play a major role in the clinical presentation of primary hyperparathyroidism (PHPT) (Broadus et al., 1980). In a recent report (Broadus et al., 1980), abnormally high circulating values of calcitriol were found in the absorptive form of the disease, characterized by high intestinal absorption of calcium, hypercalciuria, high incidence of renal stones, whereas normal to high-normal values of calcitriol were observed in non-absorptive form of the disease, with normal intestinal absorption of calcium, normal calciuria and low incidence of renal stones. However, the differences in serum calcitriol values could not be explained on the basis of differences in any of the variables currently regarded as modulating the renal production of calcitriol (Broadus et al., 1980).
KeywordsGlomerular Filtration Rate Primary Hyperparathyroidism Renal Mass Renal Stone Serum Phosphorus
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