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Effects of 1,25(OH)2D3 Administration on Serum Bone GLA Protein in Predialysis Chronic Renal Failure

  • Giorgio Coen
  • Sandro Mazzaferro
  • Giuseppe Donato
  • Carlo Massimetti
  • Paola Ballanti
  • Franco Bondatti
  • Carlo Della Rocca
  • Antonella Smacchi
  • Flavia Mantazzoli
  • Giulio A. Cinotti
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 208)

Abstract

The bone GLA protein (BGP) or osteocalcin, is a vitamin K-dependent protein produced by the osteoblasts (1), which accumulates in the non-collagenous protein fraction of bone, but it is also measurable by radioimmunoassay in the serum (2). In vitro (1) and experimental in vivo studies (3) have shown that production of this protein is modulated by 1,25(OH)2D3. However a basal production of BGP can be observed even in the vitamin D depleted animal (3). In predialysis chronic renal failure serum BGP levels are higher than normal (4) in spite of the known 1,25(OH)2D3 deficit (5).

Keywords

Chronic Renal Failure Secondary Hyperparathyroidism Serum Alkaline Phosphatase Serum iPTH Histomorphometric Evaluation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Giorgio Coen
    • 1
  • Sandro Mazzaferro
    • 1
  • Giuseppe Donato
    • 1
  • Carlo Massimetti
    • 1
  • Paola Ballanti
    • 2
  • Franco Bondatti
    • 1
  • Carlo Della Rocca
    • 2
  • Antonella Smacchi
    • 1
  • Flavia Mantazzoli
    • 1
  • Giulio A. Cinotti
    • 1
  1. 1.Division of Nephrology“La Sapienza” UniversityRomeItaly
  2. 2.Department of Human Biopathology“La Sapienza” UniversityRomeItaly

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