Impaired Intestinal Calcium Transport in the Spontaneously Hypertensive Rat

  • P. A. Lucas
  • T. Drueke
  • B. Lacour
  • R. C. Brown
  • D. A. McCarron
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 208)

Abstract

The spontaneously hypertensive rat (SHR) exhibits a variety of abnormalities in its handling of calcium (1–3) and phosphorus (4,5) and calcium supplementation has been shown to reduce its arterial blood pressure (3,6). The relationship between disturbed calcium and phosphorus metabolism and hypertension, however, remains unclear. Several investi­gators have studied intestinal calcium transport in the SHR and have reported increased (7,8), unchanged (9) or decreased (10) absorption compared with its genetic control, the Wistar­Kyoto rat (WKY). In these studies, Ca2+ absorption has been determined by means of intestinal perfusion (10) or in situ uptake (8) in vivo,everted gut sacs in vitro (7,9,10), or by balance studies (8). The variety of experimental systems employed may in part explain the diversity in these findings. We have recently addressed this issue utilising the modified Ussing apparatus (11) which permits continuous monitoring of tissue viability and the study of active intestinal calcium transport under electrically controlled conditions.

Keywords

Short Circuit Current Ussing Chamber Intestinal Perfusion Intestinal Calcium Transport Renal Phosphate Excretion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    J.P. Noon, P.J. Rice, and R.J. Baldessarini, Calcium leakage as a cause of the high resting tension in vascular smooth muscle from the spontaneously hypertensive rat. Proc.Natl. Acad. Sci. USA 75: 1605 (1978).CrossRefGoogle Scholar
  2. 2.
    G.L. Wright, and G.O. Rankin, Concentrations of ionic and total calcium in plasma of four models of hypertension. Am. J. Physiol. 243: H365 (1982).Google Scholar
  3. 3.
    D.A. McCarron, N.N. Yung, B.A. Ugoretz, and S. Krutzik, Disturbances of calcium metabolism in the spontaneously hypertensive rat. Hypertension 3 (suppl. I): I - 162 (1981).Google Scholar
  4. 4.
    C.H. Hsu, P.S. Chen, and R.M. Caldwell, Renal phosphate excretion in spontaneously hypertensive and normotensive Wistar Kyoto rats. Kidney Int. 25: 789 (1984).CrossRefGoogle Scholar
  5. 5.
    R.J. Bindels, J.A. Geertsen, C.H. van Os, and J.F. Slegers, Disturbed phosphate homeostasis in sponteneously hypertensive rats. Kidney Int. 27: 703 (1985).CrossRefGoogle Scholar
  6. 6.
    S. Ayachi, Increased dietary calcium lowers blood pressure in the spontaneously hypertensive rat. Metabolism 28: 1234 (1979).CrossRefGoogle Scholar
  7. 7.
    M.A. Toraason, and G.L. Wright, Transport of calcium by duodenum of spontaneously hypertensive rat. Am. J. Physiol. 241: G344 (1981).Google Scholar
  8. 8.
    K. Lau, J. Zikos, J. Spirnak, and B. Eby, Evidence for an intestinal mechanism in hypercalciuria of the spontaneously hypertensive rat. Am. J. Physiol. 247: E625 (1984).Google Scholar
  9. 9.
    N. Stern, D.B.N. Lee, V. Silis, F.W. Beck, L. Deftos, S.C. Manolagas, and J.R. Sowers, Effects of high calcium intake on blood pressure and calcium metabolism in young SHR. Hypertension 6: 639 (1984).Google Scholar
  10. 10.
    H.P. Schedl, D.L. Miller, J.M. Pape, R.L. Horst, and H.D. Wilson, Calcium and sodium transport and vitamin D metabolism in the spontaneously hypertensive rat. J. Clin. Invest. 73: 980 (1984).CrossRefGoogle Scholar
  11. 11.
    M.W. Walling, and D.V. Kimberg, Active secretion of calcium by adult rat ileum and jejunum in vitro. Am. J. Physiol. 225: 415 (1973).Google Scholar
  12. 12.
    M.W. Walling, and D.V. Kimberg, Effects of 1,25-dihydroxyvitamin D3 and Solanum Glaucophyllum on intestinal calcium and phosphate transport and on plasma Ca, Mg, and phosphorus levels in the rat. Endocrinol. 97: 1567 (1978).CrossRefGoogle Scholar
  13. 13.
    S.G. Schulz, and R. Zalusky, Ion transport in isolated rabbit ileum, short circuit current and Na+ fluxes. J. Gen. Physiol. 47: 567 (1964).Google Scholar
  14. 14.
    P. Ireland and J.S. Fordtran, Effect of dietary calcium and age on jejunal calcium absorption in humans studied by intestinal perfusion. J. Clin. Invest. 52: 2672 (1973).CrossRefGoogle Scholar
  15. 15.
    D.A. McCarron, P.A. Lucas, B. Lacour, R.J. Shneidman, and T. Drüeke, Blood pressure development of the spontaneously hypertensive rat following concurrent manipulations of dietary Ca2+ and Na+ : relation to intestinal Ca2+ fluxes. J. Clin. Invest. (in press).Google Scholar

Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • P. A. Lucas
    • 1
  • T. Drueke
    • 1
  • B. Lacour
    • 1
  • R. C. Brown
    • 2
  • D. A. McCarron
    • 3
  1. 1.INSERM U90, Hopital NeckerParisFrance
  2. 2.Dept. of Medical BiochemistryUniv. of Wales College of MedicineCardiffUK
  3. 3.Oregon Health Sciences UniversityPortlandUSA

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