Analysis of Calcium Transport in Rat Intestine

  • F. Bronner
  • D. Pansu
  • W. D. Stein
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 208)


Transmural calcium absorption is the resultant of two processes: a saturable, regulatable process that traverses the cell and a non-saturable, non-regulated process that is largely paracellular. This article will summarize findings and analyses in support of this generalization and provide details of the action of vitamin D, the primary regulator of active calcium absorption.


Calcium Transport Duodenal Loop Fractional Calcium Absorption Intestinal Calcium Transport Active Calcium Transport 
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  1. 1.
    H.P. Schedl, AL. Miller and N. Iskandarani, Small intestinal site, calcium transport kinetics, and calcium homeostasis in the hamster, in: “Calcium and Phosphate Transport Across Biomembranes”, F. Bronner and M. Peterlik, eds., Academic Press, New York (1981).Google Scholar
  2. 2.
    A.E. Zornitzer, and F. Bronner, In situ studies of calcium absorption in rats, Am. J. Physiol., 220: 1261–1265 (1971).Google Scholar
  3. 3.
    D. Pansu, C. Bellaton and F. Bronner, The effect of calcium intake on the saturable and non-saturable components of duodenal calcium transport, Am. J. Physiol., 2140: G32 - G37 (1981).Google Scholar
  4. 4.
    D. Pansu, C. Bellaton and F. Bronner, Developmental changes in the mechanisms of duodenal calcium transport in the rat, Am. J. Physiol, 244: G20 - G26 (1983).Google Scholar
  5. 5.
    D. Pansu, C. Bellaton, C. Roche and F. Bronner, Duodenal and ileal calcium absorption in the rat and effects of vitamin D, Am. J. Physiol., 244: 6695 - G700 (1983).Google Scholar
  6. 6.
    R.H. Wasserman, and A.N. Taylor, Some aspects of the intestinal absorption of calcium, with special reference to vitamin D, in: “Mineral Metabolism: An Advanced Treatise”, C.L. Comar and F. Bronner, eds., Academic Press, New York and London (1969).Google Scholar
  7. 7.
    F. Bronner, D. Pansu, and W.D. Stein, An analysis of intestinal calcium transport across the intestine. “Editorial Review”, Am. J. Physiol. (submitted).Google Scholar
  8. 8.
    J. Wrobel and G. Nagel, Diurnal variations of active calcium transport in the intestine of the pregnant and lactating rat, Biomedicine, 33: 143–145 (1980).Google Scholar
  9. 9.
    J.J. Feher, and R.J. Wasserman, Intestinal calcium-binding protein and calcium absorption in cortisol-treated chicks: Effects of’ vitamin D33 and 1,25-dihydroxyvitamin D3, Endocrinology, 104: 547–551 (1971).CrossRefGoogle Scholar
  10. 10.
    A. Miller III, and F. Bronner, Calcium uptake in isolated brush-border vesicles from rat small intestine, Biochem. J., 196: 391–401 (1981).Google Scholar
  11. 11.
    A. Miller III, T.-H. Ueng, and F. Bronner, Isolation of a vitamin D-dependent, calcium-binding protein from brush borders of rat duodenal mucosa, FEBS Letters, 103: 319–322 (1979).CrossRefGoogle Scholar
  12. 12.
    S. Kowarski and D. Schachter, Intestinal membrane calcium-binding protein: Vitamin D-dependent membrane component of the intestinal calcium transport mechanism, J. Biol. Chem., 255: 10834–10840 (1980).Google Scholar
  13. 13.
    A. Miller III, S.T. Li, and F. Bronner, Characterization of calcium binding to brush border membranes from rat duodenum, Biochem. J., 208: 773–782 (1982).Google Scholar
  14. 14.
    W.E.J.M. Ghijsen, M.D. DeJong, and C.H. van Os, ATP-dependent calcium transport and its correlation with Ca2+-ATPase activity in basolateral plasma membranes of rat duodenum, Biochim. Biophys. Acta, 689: 327–336 (1982).CrossRefGoogle Scholar
  15. 15.
    C. Roche, D. Pansu, and F. Bronner, The effect of trifluoperazine on transepithelial calcium transport in rat duodenum, in: “Epithelial Calcium and Phosphate Transport: Molecular and Cellular Aspects”, F. Bronner and M. Peterlik, eds., Alan Liss, New York (1984).Google Scholar
  16. 16.
    C. Roche, D. Bellaton, D. Pansu, and F. Bronner, Simultaneous induction of CaBP and active calcium transport in rat duodenum by 1,25-dihydroxyvitamin D in: “Epithelial Calcium and Phosphate Transport: Molecular and 76–1lular Aspects”, F. Bronner and M. Peterlik, eds., Alan R. Liss, New York (1984).Google Scholar
  17. 17.
    H. Schiff, and U. Binswager, Calcium ATPase and intestnal calcium transport in uremic rats, Am. J. Physiol., 238: G424 - G428 (1980).Google Scholar
  18. 18.
    R.H. Kretsinger, J.E. Mann and J.G. Simmons, Model of the facilitated diffusion of calcium by the intestinal calcium binding protein, in: “Vitamin D. Chemical, Biochemical and Clinical Endocrinology of Calcium Metabolism”, A.W. Norman, K. Schaefer, D.V. Herrath, and H.-G. Gringoleit, eds, DeGruyter, Berlin and New York (1982).Google Scholar
  19. 19.
    D.D. Bikle, D.M. Shoback, and S.J. Munson, 1,25-dihydroxyvitamin D increases the intracellular free calcium concentration of duodenal epithelial cells, “Abstracts”, Sixth Workshop on Vitamin D, Merano, Italy (1985).Google Scholar
  20. 20.
    F. Bronner, D. Pansu, A. Bosshard, J.H. Lipton, Calcium uptake by isolated rat intestinal cells, J. Cell Physiol., 116: 322–328, (1983).CrossRefGoogle Scholar
  21. 21.
    M.M. Weiser, J.H. Bloor, A. Dasmahapatra, R.A. Freedman and J.A. MacLaughlin, Vitamin D-dependent rat intestinal Ca2+ transport Ca2+ uptake by Golgi membranes and early nuclear events, in: “Calcium and Phosphate Transport Across Biomembranes”, F. Bronner and M. Peterlik, eds., Academic Press, New York (1981).Google Scholar
  22. 22.
    M. Thomasset, C.-0. Parkes and P. Cuisinier-Gleizes, Rat calcium-binding proteins: distribution, development and vitamin D-dependence, Am. J. Physiol, 243: E483 - E488 (1982).Google Scholar
  23. 23.
    H.N. Nellans, and D.V. Kimberg, Cellular and paracellular calcium transport in rat ileum: effects of dietary calcium, Am. J. Physiol., 236: E726 - E737 (1978).Google Scholar

Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • F. Bronner
    • 1
  • D. Pansu
    • 1
    • 2
  • W. D. Stein
    • 1
    • 3
  1. 1.Department of Oral BiologyUniversity of Connecticut Health CenterFarmingtonUSA
  2. 2.INSERM U-45 and EPHEHopital E. HerriotLyon Cedex 08France
  3. 3.Department of Biological Chemistry, Institute of Life SciencesHebrew UniversityJerusalemIsrael

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