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Mechanism of Phosphate Transport Adaptation in Rat Intestinal and Renal Brush Border Membranes

  • G. Danisi
  • J. Caverzasio
  • J-Ph. Bonjour
  • H. Murer
  • R. W. Straub
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 208)

Abstract

Studies on the regulation of phosphate (Pi) transport in gut and kidney have revealed an adaptation of Pi transport under dietary restriction of Pi. In response to low Pi diet, Pi absorption is enhanced in kidney and small intestine (1,2). In kidney, this stimulation results, at least in part, from the increase in the capacity of the sodium-Pi cotransport process located in the brush border membrane of the proximal tubule. The Km of the transport process is not modified (3). It is not known, to the best of our knowledge, whether the adaptation of Pi absorption in small intestine is expressed at the brush border membrane level and how these changes occur, if any. Furthermore, since sodium is cotransported with phosphate in the luminal membrane of renal and intestinal tissues, it could be that an alteration of the dependency of the phosphate carrier on sodium played some role in the stimulation of Pi transport.

Keywords

Brush Border Membrane Brush Border Membrane Vesicle Renal Brush Border Membrane Renal Brush Border Membrane Vesicle Intestinal Brush Border Membrane Vesicle 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Cramer, C.F. and J. McMillan. Amer.J.Physiol. 239: G261 - G265, 1980Google Scholar
  2. 2.
    Bonjour, J-Ph. and J. Caverzasio. Rev.Physiol.Biochem.Pharmacol. 100: 161–214, 1984Google Scholar
  3. 3.
    Stoll, R., R. Kinne and H. Murer. Biochem.J. 180: 465–470, 1979Google Scholar
  4. 4.
    Caverzasio, J. and J-Ph. Bonjour. Pflügers Arch. 404: 227–232, 1985CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • G. Danisi
    • 1
  • J. Caverzasio
    • 1
  • J-Ph. Bonjour
    • 1
  • H. Murer
    • 1
  • R. W. Straub
    • 1
  1. 1.Department of Pharmacology and Division of PathophysiologyUniversity of GenevaSwitzerland

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