Renal Magnesium Wasting Disorders
Hypomagnesemia and magnesium deficiency may be due to gastrointestinal malabsorption, poor dietary intake or renal (tubular) magnesium wasting. Magnesium wasting would result in hypomagnesemia if dietary magnesium intake is insufficient. A number of causes of magnesium wasting have been identified including congenital or primary renal magnesium wasting, hyperaldosteronism, Bartter’s syndrome, diabetic ketoacidosis, acute alcohol intake and hypercalcemia with hypercalcuria. More recently attention has focussed on renal magnesium wasting due to drugs including diuretics, antibiotics, chemotherapeutic and immunosuppressive agents. One can consider renal magnesium wasting as an exaggerated physiological response due to pharmacological or toxic impairment of normal tubular magnesium reabsorption. It is clear that the ensuing hypomagnesemia is dependent on the dietary magnesium intake and the overall cellular magnesium depletion does not necessarily occur in a predictable fashion.
KeywordsProximal Tubule Loop Diuretic Magnesium Transport Magnesium Excretion Osmotic Diuretic
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- 1.G. A. Quamne and J. H. Dirks, Magnesium: Cellular and Renal Exchanges, in “The Kidney, Physiology and Pathophysiology.” D. W. Seldin and G. Giebisch, ed., Raven Press, New York (1985).Google Scholar
- 4.G. R. Shareghi and Z. S. Agus, PTH - Sensitive magnesium transport in the rabbit cortical thick ascending limb of Henle. (CTAL) Kidney Int. 16:S37A (1979).Google Scholar
- 5.N. L. M. Wong, G. A. Quamme, and J. H. Dirks, Influence of Bicarbonate on the Renal Handling of Magnesium, in: “Urolithiasis, Clinical and Basic Research.” L. H. Smith, W. G. Robertson, and B. Finleyson, ed., Plenum Press, New York (1984).Google Scholar
- 8.P. 0. Wester and T. Dyckner, Diuretic treatment and magnesium losses. Acta Medica. Scand. 647 (Suppl.): 145 (1981).Google Scholar
- 9.G. A. Quamme, Effect of furosemide on calcium and magnesium transport in the rat nephron. Am. J. Physiol. 241: 340 (1981).Google Scholar
- 10.N. L. M. Wong, G. A. Quamme, R. A. L. Sutton, and J. H. Dirks, Effect of mannitol on water and electrolyte transport in the dog kidney. J. Lab. and Clin. Med. 94: 683 (1979).Google Scholar
- 13.J. Devane and M. P. Ryan, Evidence for a magnesium-sparing action by amiloride during renal clearance studies in rats. Br. J. of Pharmacol. 78: 891 (1983).Google Scholar
- 14.R. L. Schilsky, A. Barlock, and R. F. Ozols, Persistent hypomagnesemia following cisplatin chemotherapy for testicular cancer. Cancer Treat. Reports 66: 1767 (1982).Google Scholar