Renal Tubular Disorders Associated with Hypocalciuria

  • Roger A. L. Sutton
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 208)


Hypocalciuria (an abnormally low urinary calcium excretion) may be absolute and relative. Robertson and Morgan1 reported that the 24-hour urinary calcium excretion of normal subjects showed a non-Gaussian distribution with a distortion at the lower end due to the build-up of values over a range of lower limits. Less than 15% of normal male subjects had urinary calcium excretions below 100mg per 24 hours. Relative hypocalciuria may be defined as a fractional or absolute urinary calcium excretion lower than would be expected on the basis of the patients’ filtered calcium load and urinary excretion of sodium. For example, in mild renal impairment (creatinine clearance 106–40m1/min.), Popovtzer et al.2 observed a significantly lower fractional calcium excretion, but a significantly higher fractional sodium excretion than normal, implying preferential renal calcium retention, which they attributed to the presence of secondary hyperparathyroidism. Hypocalciuria may result from the actions of several factors known to enhance renal calcium reabsorption, including parathyroid hormone (PTH)3, metabolic alkalosis4, thiazide diuretics5, hypocalcemia6, and perhaps hypomagnesia7 and vitamin D deficiency. Hypocalciuria cannot therefore be confidently attributed to a primary renal tubular defect unless these factors have been excluded as contributing causes. Absolute or relative hypocalciuria may be observed in patients with low, normal or high serum calcium levels.


Urinary Calcium Excretion Distal Convoluted Tubule Renal Calcium Calcium Reabsorption Familial Hypocalciuric Hypercalcemia 
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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Roger A. L. Sutton
    • 1
  1. 1.Department of MedicineUniversity of British ColumbiaVancouverCanada

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