Calcium Transport in the Distal Convoluted Tubule

  • Linda S. Costanzo
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 208)


In 1963, Lassiter and coworkers, using micropuncture techniques, provided the first quantitative assessment of calcium transport along the nephron (1). Compiling their data and those of subsequent investigators, it is apparent that about 65% of the filtered calcium load is reabsorbed in the proximal convoluted tubule, another 25% in the loop of Henle and about 8% in the distal tubule. While the quantitative contribution of the distal convoluted tubule seems small, it should be noted that comparably small fractions of sodium and water are reabsorbed distally (2). At the same time, the distal nephron is a major regulatory site for these substances (2). Thus it seemed worthwhile to characterize distal tubular calcium transport and to study the potential hormonal regulation and effects of diuretic agents.


Distal Tubule Calcium Transport Sodium Transport Distal Convoluted Tubule Proximal Convoluted Tubule 
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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Linda S. Costanzo
    • 1
  1. 1.Department of Physiology and BiophysicsMedical College of VirginiaRichmondUSA

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