Calcium Transport by the Proximal Tubule

  • Fred S. Wright
  • Karol Bomsztyk
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 208)


The proximal tubule contributes to renal handling of calcium by reabsorbing approximately 60% of the filtered quantity (Lassiter et al., 1963). Studies employing in vivo and in vitro perfusion of single proximal tubules have begun to provide some information about the transport mechanisms that contribute to recovery of filtered calcium by the proximal tubule.


Proximal Tubule Calcium Transport Perfusion Fluid Tubule Fluid Transepithelial Voltage 
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  1. Agus, A. Z., Gardner, L. B., and Beck, L. H., 1973, Effect of parathyroid hormone on renal tubular reabsorption of calcium, sodium, and phosphate, Am. J. Physiol., 224: 1143.Google Scholar
  2. Beck, L. H., and Goldberg, M., 1973, Effects of acetazolamide and parathyroidectomy on renal transport of sodium, calcium, and phosphate, Am. J. Physiol., 224: 1136.Google Scholar
  3. Bomsztyk, K., and Wright, F.S., 1982, Effects of transepithelial fluid flux on transepithelial voltage and transport of calcium, sodium, chloride, and potassium by renal proximal tubule, Kidney Int., 21: 269.Google Scholar
  4. Bomsztyk, K., and Wright, F. S., 1983, Calcium absorption by proximal tubule stimulated by reducing luminal sodium concentration, Kidney Int., 23: 95.Google Scholar
  5. Bomsztyk, K., George, J. P., and Wright, F. S., 1984, Effects of luminal fluid anions on calcium transport by proximal tubule, Am. J. Physiol., 246 (Renal Fluid Electrolyte Physiol. 15): F600.Google Scholar
  6. Corman, B., and DiStephano, A., 1983, Evidence for movement of water without solutes through kidney proximal tubule, Kidney Int., 23:252A.Google Scholar
  7. Edwards, B. R., Baer, P. G., Sutton, R. A. L., and Dirks, J. H., 1973 Micropuncture study of diuretic effects on sodium and calcium reabsorption in the dog nephron, J. Clin. Invest., 52: 2418.CrossRefGoogle Scholar
  8. Hierho1zer, K., Kawamura, S., Seldein, D. W., Kokko, J. P., and Jacobson, H.R., 1980, Reflection coefficients of various substrates across superficial and juxtamedullary proximal convoluted segments of rabbit nephrons, Mineral Electrolyte Metab., 3: 172.Google Scholar
  9. Jacobson, H. R., Kokko, J. P., Seldin, D. W., and Holmberg, C., 1982, Lack of solvent drag of NaC1 and NaHCO3 in rabbit proximal tubules, Am. J. Physiol., 243 (Renal Fluid Electrolyte Physiol. 12): F342.Google Scholar
  10. Lassiter, W. E., Gottschalk, C. W., and Mylle, M., 1963, Micropuncture study of renal tubular reabsorption of calcium in normal rodents, Am. J. Physiol., 204: 771.Google Scholar
  11. Murayama, Y., Morel, F., and LeGrimellec, C., 1972, Phosphate, calcium and magnesium transfers in proximal tubules and loops of Henle, as measured by single nephron microperfusion experiments in the rat, Pflugers Arch., 333: 1.CrossRefGoogle Scholar
  12. Ng, R.C.K., Rouse, D., and Suki, W.N., 1984, Calcium transport in the rabbit superficial proximal convoluted tubule, J. Clin. Invest., 74: 834.Google Scholar
  13. Poujeol, P., Chabardes, G, Roinel, N., and de Rouffignac, C., 1976, Influence of extracellular fluid volume expansion on magnesium, calcium, and phosphate handling along the rat nephron, Pflugers Arch., 365: 203.CrossRefGoogle Scholar
  14. Suki, W. N., 1979, Calcium transport in the nephron, Am. J. Physiol., 237 (Renal Fluid Electrolyte Physiol. 6): F1.Google Scholar
  15. Ullrich, K. J., 1973, Permeability characteristics of the mammalian nephron, and F. Sauer, Appendix: Nonequilibrium thermodynamics of kidney tubule transport, in: “Handbook of Physiology, Renal Physiology”, J. Orloff, and R.W. Berliner, eds., Am. Physiol. Soc., Washington, D.C..Google Scholar
  16. Ullrich, K. J., Rumrich, G., and Kloss, S., 1976, Active Ca++ reabsorption in the proximal tubule of the rat kidney, Pflugers Arch.. 364: 223.Google Scholar
  17. Walser, M., 1961, Calcium clearance as a function of sodium clearance in the dog, Am. J. Physiol., 200: 1099.Google Scholar

Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Fred S. Wright
    • 1
  • Karol Bomsztyk
    • 2
  1. 1.VA Medical CenterYale UniversityNew HavenUSA
  2. 2.Nephrology DivisionUniversity of WashingtonSeattleUSA

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