Effects of Glucagon on Renal and Extrarenal Handling of Pi in Rodents: Evidence for Pi Mobilizing Activity

  • R. C. Mühlbauer
  • J.-P. Bonjour
  • H. Fleisch
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 208)


Glucagon is known to be released during fasting (1) and between meals (2), and it is generally accepted that the presence of this hormone is important in the prevention of hypoglycemia. Furthermore, glucagon has also been found to be phosphaturic in man (3) and animals (4, 5) fed diets containing normal amounts of inorganic phosphate (Pi). Since these phosphaturic effects are associated with decrements in Plasma Pi concentration ([Pi]P1.) one has to conclude that glucagon had acted through a change in the renal handling of Pi.


Malachite Green High Phosphorus Hormone Infusion Glucagon Injection Glucagon Infusion 
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  1. 1.
    Saudek, C.D., P.R. Boulter, and R.A. Arky. The natriuretic effect of glucagon and its role in starvation. J. Clin. Endocrinol. Metab. 36: 761–765, 1973.CrossRefGoogle Scholar
  2. 2.
    Unger, R.H. Insulin-glucagon relationships in the defense against hypoglycemia. Diabetes 32: 575–583, 1983.Google Scholar
  3. 3.
    Elrick, H., E.R. Huffman, C.J. Hlad jr., N. Whipple, and A. Staub. Effects of glucagon on renal function in man. J. Clin. Endocrinol. and Metab. 18: 813–824, 1958.CrossRefGoogle Scholar
  4. 4.
    Bailly, C., and C. Amiel. Effect of glucagon on magnesium renal reabsorption in the rat. Pflügers Arch. 392: 360–365, 1982.CrossRefGoogle Scholar
  5. 5.
    Butlen, D., and S. Jard. Renal handling of 3’-5’-cyclig AMP in the rat. The possible role of luminal 3’-5’-cyclic AMP in the tubular reabsorption of phosphate. Pflügers Arch. 331: 172–190, 1972.Google Scholar
  6. 6.
    Gloor, H.J., J.-P. Bonjour, J. Caverzasio, and H. Fleisch. Resistance to the phosphaturic and calcemic actions of parathyroid hormone during phosphate depletion. Prevention by 1,25-dihydroxyvitamin D3. J. Clin. Invest. 63: 371–377, 1979.CrossRefGoogle Scholar
  7. 7.
    Steele, T.H., J.L. Underwood, B.A. Stromberg, and C.A. Larmore. Renal resistance to parathyroid hormone during phosphorus deprivation. J. Clin. Invest. 58: 1461–1464, 1976.CrossRefGoogle Scholar
  8. 8.
    Steele, T.H., and H.F. DeLuca. Influence of dietary phosphorus on renal phosphate reabsorption in the parathyroidectomized rat. J. Clin. Invest. 57: 867–874, 1976.CrossRefGoogle Scholar
  9. 9.
    Tröhler, U., J.-P. Bonjour, and H. Fleisch. Inorganic phosphate homeostasis. Renal adaptation to the dietary intake in intact and thyroparathyroidectomized rats. J. Clin. Invest. 57: 264–273, 1976.CrossRefGoogle Scholar
  10. 10.
    Mühlbauer, R.C., J.-P. Bonjour, and H. Fleisch. Tubular localization of adaptation to dietary phosphate in rats. Am. J. Physiol. 233 (Renal Fluid Electrolyte Physiol. 2): F342 - F348, 1977.Google Scholar
  11. 11.
    Franke, H., G. Gronow, and K. Petersen. Glucagon induced funtional changes of isolated perfused rat kidney. Curr. Probl. Clin. Biochem. 8: 424–434, 1977.Google Scholar
  12. 12.
    Levy, M. The effect of glucagon on glomerular filtration rate in dogs during reduction of renal blood flow. Can. J. Physiol. Pharmacol. 53: 660–668, 1975.CrossRefGoogle Scholar
  13. 13.
    Parving, H.-H., J. Noer, H. Kehlet, C.E. Morgensen, P. Aa. Svendsen, and L. Heding. The effect of short-term glucagon infusion on kidney function in normal man. Diabetologia 13: 323–325, 1977.CrossRefGoogle Scholar
  14. 14.
    Uranga, J., R. Fuenzalida, A.L.Rapoport, and E. del Castillo. Effect of glucagon and glomerulopressin on the renal function of the dog. Horm. Metab. Res. 11: 275–279, 1979.Google Scholar
  15. 15.
    Mühlbauer, R.C., J.-P. Bonjour, and H. Fleisch. Abnormal hyperphosphatemic response to fasting in X-linked hypophosphatemic mice. Min. Electrol. Metab. 10: 362–365, 1984.Google Scholar
  16. 16.
    Talmage, R.V., S.H. Doppelt, and J.H. Postma jr. Observations on the relationship of parathryoid hormone and calcitonin to plasma and liver phosphate. Proc. Soc. Exp. Biol. Med. 153: 131–137, 1976.Google Scholar
  17. 17.
    Talmage, R.V., C.J. VanderWiel, and D.B. Raneri. Fac Srs affecting parathyroid hormone-induced hypophosphatemia and P specific activity in thyroparathyroidectomized rats. Calcif. Tissue Res. 27: 239–246, 1979.CrossRefGoogle Scholar
  18. 18.
    Blackard, W.G., N.C. Nelson, and S.S. Andrews. Portal and peripheral vein immunoreactive glucagon concentrations after arginine or glucose infusions. Diabetes 23: 199–202, 1974.Google Scholar

Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • R. C. Mühlbauer
    • 1
  • J.-P. Bonjour
    • 1
  • H. Fleisch
    • 1
  1. 1.Department of PathophysiologyUniversity of BernBernSwitzerland

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