Calcium Stimulates Sodium-Dependent Phosphate Absorption in Rabbit Proximal Convoluted Tubules Perfused in Vitro

  • Diane Rouse
  • Wadi N. Suki
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 208)


There has been considerable evidence for an effect of calcium on the absorption of phosphate by the kidney. Two micropuncture studies have agreed that increasing serum calcium enhances distal nephron phosphate absorption.1,2 However, in the proximal tubule, one study found enhancement of phosphate absorption,1 the other inhibition.2 Because the various indirect effects of increasing serum calcium may have played a role in the outcome of in vivo studies, an in vitro study using the technique of isolated tubule microperfusion was designed.


Phosphate Absorption Bath Temperature Phosphate Transport Proximal Convoluted Tubule Tubule Segment 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    C. Amiel, H. Kuntziger, S. Couette, C. Coureau, and N. Bergounioux. Evidence for a parathyroid hormone-independent calcium modulation of phosphate transport along the nephron. J. Clin. Invest. 57: 256 (1976).CrossRefGoogle Scholar
  2. 2.
    S. Goldfarb, P. Bosanac, M. Goldberg, and Z.S. Agus. Effects of calcium on renal tubular phosphate reabsorption. Am. J. Physiol. 234: F22 (1978).Google Scholar
  3. 3.
    M. Burg, J. Grantham, M. Abramow, and J. Orloff. Preparation and study of fragments for single rabbit nephrons. Am. J. Physiol. 210: 1293 (1966).Google Scholar
  4. 4.
    A.S. Rocha and J.P. Kokko. Sodium chloride and water transport in the medullary thick ascending limb of Henle. J. Clin. Invest. 52: 612 (1973).CrossRefGoogle Scholar
  5. 5.
    D. Rouse, R.C.K. Ng, and W.N. Suki. Calcium transport in the pars recta and thin descending limb of Henle of the rabbit, perfused in vitro. J. Clin. Invest. 65: 37 (1980).CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Diane Rouse
    • 1
  • Wadi N. Suki
    • 1
  1. 1.Baylor College of MedicineThe Methodist HospitalHoustonUSA

Personalised recommendations