Brush Border Membrane Phosphate Transport Effects of Volume Expansion

  • Jules B. Puschett
  • Joseph Liput
  • Christopher Galya
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 208)


Volume expansion reproducibly results in the development of phosphaturia both in the experimental animal1–4 and in man.5, 6 Although there is evidence that the expansion procedure reduces phosphate reabsorption at more than one site within the nephron,7 the proximal tubule is considered to be a major source of the excreted phosphate, based largely upon micropuncture experi-ments.3, 8–10 This would be expected, since the majority of filtered phosphate appears to be reabsorbed in the proximal nephron,11 at least in animals with intact parathyroid glands.12, 13 When the parathyroid glands are removed however, phosphate transport in later nephron segments appears to be enhanced such that volume expansion is less phosphaturic in parathyroidectomized than in intact animals. 1, 13, 14


Volume Expansion Brush Border Membrane Phosphate Transport Phosphate Uptake Brush Border Membrane Vesicle 
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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Jules B. Puschett
    • 1
  • Joseph Liput
    • 1
  • Christopher Galya
    • 1
  1. 1.Renal-Electrolyte Division, Department of MedicineUniversity of Pittsburgh, School of Medicine, and the Presbyterian-University and Veterans Administration HospitalsPittsburghUSA

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