The CT Normal But Low Flow Infarct Periphery: Selective Neuronal Necrosis?

  • Jens Astrup
  • M. Nedergaard
  • L. Klinken
Part of the NATO ASI Series book series (NSSA, volume 115)


Large infarcts in the MCA territory usually appear sharply demarcated from tissue of normal attenuation on CT. On 133-Xenon inhalation blood flow tomography, on the other hand, infarcts appear surrounded by a wide borderzone of low blood flow (1). Such low flow in the CT normal infarct periphery can be explained as low function and metabolism either due to deafferentiation and disconnection of neurons in the infarct surroundings, or as so-called incomplete infarction with CT invisible microfoci of infarction and wider zones of selective loss of neurons (2,3,4). This study explores the latter possibility.


Cereb Blood Flow Normal Attenuation Normal Cortex Cortex Thickness Ischemic Brain Lesion 
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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Jens Astrup
    • 1
  • M. Nedergaard
    • 2
  • L. Klinken
    • 2
  1. 1.Department of Neurosurgery, RigshospitaletUniversity of CopenhagenDenmark
  2. 2.Institute of NeuropathologyUniversity of CopenhagenDenmark

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