The CT Normal But Low Flow Infarct Periphery: Selective Neuronal Necrosis?
Large infarcts in the MCA territory usually appear sharply demarcated from tissue of normal attenuation on CT. On 133-Xenon inhalation blood flow tomography, on the other hand, infarcts appear surrounded by a wide borderzone of low blood flow (1). Such low flow in the CT normal infarct periphery can be explained as low function and metabolism either due to deafferentiation and disconnection of neurons in the infarct surroundings, or as so-called incomplete infarction with CT invisible microfoci of infarction and wider zones of selective loss of neurons (2,3,4). This study explores the latter possibility.
KeywordsCereb Blood Flow Normal Attenuation Normal Cortex Cortex Thickness Ischemic Brain Lesion
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