Microthrombosis: A Contributing Factor to the Progression of Cerebral Infarction in Man

  • J. Cervos-Navarro
  • J. Figols
  • G. Ebhardt
Part of the NATO ASI Series book series (NSSA, volume 115)


Eighty percent of strokes are the consequence of cerebral infarcts resulting from occlusion of a large vessel (Cervos-Navarro, 1980). Furthermore, non-occlusive mural thrombi can be the source of emboli and of embolic cerebral infarcts in the territories of major cerebral arteries. Various diseases affecting the whole organism can lead to micro-thrombosis of brain vessels, such as polycythemia vera, leukaemia, consumption coagulopathy, etc. Relatively little attention has been paid to the role of microthrombosis in progressive stroke. A significance of microthrombosis has only been considered in watershed infarcts (Romanul and Abramowic, 1964). We have focussed our attention on the role of microthrombosis as a possible factor of further progression of brain infarcts.


Cerebral Infarction Polycythemia Vera Consumption Coagulopathy Meningeal Vessel Watershed Infarct 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Baumgartner HR, The role of blood flow in platelet adhesion, fibrin deposition and formation of mural thrombi, Microvasc Res 5: 167 (1973).CrossRefGoogle Scholar
  2. Cervos-Navarro J, Hirninfarkt, in: “Spezielle pathologische Anatomie”, Bd. 13/I, Doerr W, Seifert G, eds., Springer-Verlag, Berlin (1980).Google Scholar
  3. Goldstein GW, Metabolism of brain capillaries in relation to active ion transport, in: Advances in neurology, Vol. 20: “Pathology of cerebrospinal microcirculation”, Cervos-Navarro J, Betz EGoogle Scholar
  4. Ebhardt G, Ferszt R, Wüllenweber R, eds., Raven Press, New York (1978).Google Scholar
  5. Kuschinsky W, Wahl M, Bosse O, Thurau K, Perivascular potassium and pH as determinants of focal pial arterial diameter in cats: A microapplication study, Circ Res 31: 240 (1972).Google Scholar
  6. Lassen NA, Luxury perfussion syndrome and its possible relation to acute metabolic acidosis within the brain, Lancet 2: 1113 (1966).CrossRefGoogle Scholar
  7. Leniger-Follert E, Urbanics R, Lübbers DW, Behavior of extracellular H+ - and K+ -activities during functional hyperemia of microcirculation in the brain cortex, in: Advances in neurology, Vol. 20: “Pathology of cerebrospinal microcirculation”, Cervos-Navarro J, Betz E, Ebhardt G, Ferszt R, Wüllenweber R, eds., Raven Press, New York (1978).Google Scholar
  8. Marcus AJ, Recent progress in the role of platelets in occlusive vascular disease, Stroke 14: 475 (1983).CrossRefGoogle Scholar
  9. Meyer JS, Importance of ischemic damage to small vessels in experimental cerebral infarction, J Neuropath Exp Neurol 17: 571 (1958).CrossRefGoogle Scholar
  10. Nelson E, Kawamura J, Sunaga T, Endothelial ischemia. Scanning (SEM) and transmission (TEM) electron microscope studies in rabbit. in: “Cerebral circulation and metabolism”, Langfitt TW, McHenry LC, Reivich M, Wollman H, eds., Springer-Verlag, New York (1975).Google Scholar
  11. Petito CK, Platelet thrombi in experimental cerebral infarction, Stroke 10: 192 (1979).CrossRefGoogle Scholar
  12. Rickenbacher J, Normale und pathologische Anatomie des Hirngefäßsystems, in: “Der Hirnkreislauf”, Gänshirt H, ed., Georg Thieme Verlag, Stuttgart (1972).Google Scholar
  13. Spatz H, Pathologische Anatomie der Kreislaufstörungen des Gehirns, Z Neurol Psychiat 167: 301 (1939).CrossRefGoogle Scholar
  14. Wolfe LS, Rostworosky K, Marion J, Endogenous formation of the prostaglandin endoperoxide metabolite thromboxane B2 by brain tissue, Biochem Biophis Res Commun 70: 907 (1976).CrossRefGoogle Scholar
  15. Zervas NT, Lavyne MH, Negoro M, Neurotransmitters and the normal and ischemic cerebral circulation, N Engl J Med 293: 812 (1975).CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • J. Cervos-Navarro
    • 1
  • J. Figols
    • 1
  • G. Ebhardt
    • 1
  1. 1.Institute of Neuropathology, Klinikum SteglitzFree University of BerlinBerlin 45Germany

Personalised recommendations