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Ischemic Brain Damage in the Rat in a Long Term Recovery Model

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Mechanisms of Secondary Brain Damage

Part of the book series: NATO ASI Series ((NSSA,volume 115))

Abstract

Since the pioneering experiments of Grenell (1), who demonstrated neuronal necrosis in dogs after periods of ischemia from only two to less than ten minutes, there has been controversy as to the minimum time necessary to produce permanent brain damage after ischemia. The maximum duration of ischemia which the animal can survive indefinitely (“revival time”) has also been the subject of some dispute, with times as long as one hour having been reported for recovery of at least basic neurophysiologic functions (2,3).

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Author information

Authors and Affiliations

  1. Laboratory for Experimental Brain Research E-Blocket, University Hospital, S-22185, Lund, Sweden

    Roland N. Auer, M.-L. Smith & B. K. Siesjö

Authors
  1. Roland N. Auer
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  2. M.-L. Smith
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  3. B. K. Siesjö
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Editor information

Editors and Affiliations

  1. University of Munich, Munich, West Germany

    A. Baethmann  & A. Unterberg  & 

  2. University of Groningen, Groningen, Holland

    K. G. Go

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© 1986 Plenum Press, New York

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Auer, R.N., Smith, ML., Siesjö, B.K. (1986). Ischemic Brain Damage in the Rat in a Long Term Recovery Model. In: Baethmann, A., Go, K.G., Unterberg, A. (eds) Mechanisms of Secondary Brain Damage. NATO ASI Series, vol 115. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5203-7_7

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  • DOI: https://doi.org/10.1007/978-1-4684-5203-7_7

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5205-1

  • Online ISBN: 978-1-4684-5203-7

  • eBook Packages: Springer Book Archive

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