Role of Cerebral Microcirculation in Secondary Brain Damage

  • George Mchedlishvili
Part of the NATO ASI Series book series (NSSA, volume 115)


The cerebral circulation plays a significant role in secondary brain damage which may result from microcirculatory disorders provoking either delayed brain edema or secondary cerebral ischemia.


Brain Edema Systemic Arterial Pressure Cerebral Microvessels Secondary Brain Damage Cerebral Microcirculation 
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  1. Chien S, Present state of blood rheology, in: “Hemodilution. Theoretical basis and clinical application”, Meßmer K, Schmid-Schönbein H, eds., Karger Basel (1972).Google Scholar
  2. Gannushkina IV, Shafranova VP, Morphological evidence and mechanism of spotty character of brain tissue damage in experimental hypertension, in: “Cerebral Vascular Disease”, Meyer JS, Lechner H, Reivich M, eds., VII Int. Conference Salzburg 1974, Stuttgart (1975).Google Scholar
  3. Häggendal E, Johansson B, Pathophysiology of the increased cerebro-vascular permeability in acute arterial hypertension, Acta Neurol Scand 48:265 (1972).CrossRefGoogle Scholar
  4. Klatzo I, Pathological opening of the BBB, in: “Cardiovascular physiology. Microcirculation and capillary exchange”, Kovach ACB, Hamar J, Szabo L, eds., Pergamon Press and Akademiai Kiado, Budapest (1981).Google Scholar
  5. Maier-Hauff K, Lange M, Schürer L, Guggenbichler C, Vogt W, Jacob K, Baethmann A, Glutamate and free fatty acid concentrations in extracellular vasogenic edema fluid, in: “Recent progress in the study and therapy of brain edema”, Go KG, Baethmann A, eds., Plenum Press, New York (1983).Google Scholar
  6. Mchedlishvili GI, “The capillary circulation”, ed., Georgian Academy of Sciences, Tbilisi (1958).Google Scholar
  7. Mchedlishvili GI, “Vascular mechanisms of the brain”, ed., Plenum Press, New York (1972).Google Scholar
  8. Mchedlishvili GI, Akhobadze VA, The cerebral arterial system in brain injury and during traumatic edema, Physiol Bohemoslov 10:8 (1961a).Google Scholar
  9. Mchedlishvili GI, Akhobadze VA, The functional state of the capillary and venous systems of the brain in cerebral traumatic edema, Physiol Bohemoslov 10:15 (1969b).Google Scholar
  10. Mchedlishvili GI, Kapuscinski A, Nikolaishvili LS, Mechanisms of post-ischemic brain edema: contribution of circulatory factors, Stroke 7:410 (1976a).CrossRefGoogle Scholar
  11. Mchedlishvili GI, Mitagvaria NP, Ormotsadze LG, Vascular mechanisms controlling a constant blood supply to the brain (“autoregulation”), Stroke 4:742 (1973).CrossRefGoogle Scholar
  12. Mchedlishvili GI, Mossakowski M, Itkis M, Sikharulidze N, Januszewski S, Cerebral blood volume changes during the development of brain edema, in: “Recent progress in the study and therapy of brain edema”, Go KG, Baethmann A, eds., Plenum Press, New York (1983).Google Scholar
  13. Mchedlishvili GI, Nikolaishvili LS, Antia RV, Are the pial arterial responses dependent on the direct effect of intravascular pressure and extravascular and intravascular pO2,pCO2 and pH?, Microvasc Res 10:298 (1976b).CrossRefGoogle Scholar
  14. Mchedlishvili GI, Sikharulidze NV, Itkis ML, Januszewski S, Effect of systemic arterial and venous pressures on cerebral blood volume, J Physiol USSR 68:64 (1982).Google Scholar
  15. Mkhejan EE, Akopov SE, Sotsky OP, Role of glycolipids in process of aggregation of erythrocytes and thrombocytes, J Exper Clin Med 21:20 (1982).Google Scholar
  16. Pappius HM, Local cerebral glucose utilization in thermally traumatized rat brain, Ann Neurol 12:157 (1976).CrossRefGoogle Scholar
  17. Pappius HM, Wolfe LF, Functional disturbances in brain following injury: Search for underlying mechanisms, Neurochem Res 8:63 (1983).CrossRefGoogle Scholar
  18. Sakharova AV, Regional peculiarities of adrenergic and cholinenergic innervation of cerebral surface vessels, Bull Exper Biol Med 88:141 (1980).Google Scholar
  19. Schmid-Schönbein H, Wells RE, Goldstone J, Influence of deformability of human red cells upon blood viscosity, Circ Res 25:131 (1969).Google Scholar

Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • George Mchedlishvili
    • 1
  1. 1.Beritashvili Institute of PhysiologyGeorgian Academy of SciencesTbilisiUSSR

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