Recent Advances in the Study of Cerebrovascular Receptors

  • Maria Spatz
Part of the NATO ASI Series book series (NSSA, volume 115)


The possibility of monoamines interaction with vascular elements in the brain under pathological conditions leading to an altered cerebro-vascular function and secondary brain injury was postulated at the time of limited knowledge about their respective receptors (33). The confirmation of this concept has been hindered by the difficulties of studying the regulatory mechanisms of the noticeably inaccessible vascular bed. Needless to say that direct proof of receptors present in the vessels and particularly in the microvessels of the brain has lingered beyond those described in the peripheral vasculature. For a long time it was thought that the cerebral arteries lack reactivities to nervous and pharmacological stimuli, even though the presence of nerve fibers in cerebral arteries was already described centuries ago by Willis. Subsequently, this opinion was overturned by electronmicroscopic, histochemical and specific immunocytochemical evidence of an existing perivascular innervation (4,6,9,11,16,17,29,36,39,43).


Cerebral Blood Flow Cerebral Artery Adenylate Cyclase Vasoactive Intestinal Polypeptide Cereb Blood Flow 
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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Maria Spatz
    • 1
  1. 1.Laboratory of Neuropathology and Neuroanatomical SciencesNINCDS, National Institutes of HealthBethesdaUSA

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