Progression and Irreversibility in Brain Ischaemia

  • Lindsay Symon
Part of the NATO ASI Series book series (NSSA, volume 115)


In recent years the twin concepts of thresholds of ischaemia and of the ischaemic penumbra have proved useful hypotheses in the investigation and management of cerebrovascular disease. This paper presents the current status of these concepts. The notion of an ischaemic threshold arose from clinical observation. It has long been clear in clinical neurosurgery, for example, that patients recovering from anaesthesia may show the progressive clearance of a neurological deficit, that some patients who develop a neurological deficit with lower blood pressure have that deficit promptly cleared when blood pressure is elevated and that patients with established cerebrovascular occlusion and dense neurological deficits may show quite evident improvement over months or years. While in this last example some of the potential for re-learned circuitry in the nervous system may play a part, it is clear that in more acute circumstances neurons which at one time are non-functioning, may under improved conditions of perfusion return to normal function.


Cerebral Blood Flow Middle Cerebral Artery Middle Cerebral Artery Occlusion Spreading Depression Brain Water Content 


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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Lindsay Symon
    • 1
  1. 1.Institute of NeurologyGough Cooper Department of Neurological SurgeryLondonUK

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