Modifications of cAMP and Creatine Kinase-Isoenzymes in CSF in Experimental Head Injury

  • Raffael Vara-Thorbeck
  • M. Ruiz-Morales
Part of the NATO ASI Series book series (NSSA, volume 115)


In previous papers we have demonstrated an increase in activity of various enzymes in CSF of patients suffering not only from traumatic brain injury but also from other cerebral diseases, such as tumors, meningoencephalitis, stroke etc. (21,27,29,30,31,37). Recent studies using computerized tomography have emphasized that brain swelling can occur immediately within 10–20 minutes after head injury (15,38). The etiology of acute brain swelling following head injury is the subject of. many, also recently conducted studies (4,7,17). Vascular dilatation (engorgement), cerebral edema (Hirnödem), or a combination of both seem to offer a most likely explanation (17). Therefore it is our opinion that cold injury of the brain which is extensively used since the studies of Clasen (5) does not seem to be a valid model, because of the etiological dissimilarity with traumatic brain swelling of patients. Aim of the present study was to analyze immediate changes of cAMP and creatine kinase (CK) in CSF employing an experimental model of cerebral concussion and contusion.


Creatine Kinase Head Injury Severe Head Injury Secondary Brain Damage Epidural Pressure 
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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Raffael Vara-Thorbeck
    • 1
  • M. Ruiz-Morales
    • 1
  1. 1.Catedra de Patologia Quirurgica, II. Facultad de MedicinaUniversidad de GranadaGranadaSpain

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