Neurochemical Sequelae of Brain Damage and Their Role in Functional Disturbances

  • Hanna M. Pappius
  • L. S. Wolfe
Part of the NATO ASI Series book series (NSSA, volume 115)


Various types of injury have been shown to produce a variety of chemical changes in brain which are thought to underly functional disturbances resulting from the particular insult. Some of the systems known to be affected in injured brain are summarized in Figure 1, but the list is by no means exhaustive. The exact mechanisms by which the chemical perturbations are related to functional disturbances are not understood in most cases and it is often difficult to distinguish between the cause and the effect in this relationship. One problem has been the difficulty in assessing neurological function in animals since normalization of neurochemical disturbances in brain cannot always be equated with normally functioning central nervous system and the available methods are not necessarily applicable in the particular experimental situation.


Arachidonic Acid Cerebral Edema Brain Damage Cereb Blood Flow Injured Brain 
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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Hanna M. Pappius
    • 1
    • 2
  • L. S. Wolfe
    • 1
    • 2
  1. 1.The Goad Unit of The Donner Laboratory of Experimental NeurochemistryMontreal Neurological Institute and HospitalMontrealCanada
  2. 2.Department of Neurology and NeurosurgeryMcGill UniversityMontrealCanada

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