Skip to main content

Primary Brain Damage in Non-Missile Head Injury

  • Chapter
Mechanisms of Secondary Brain Damage

Part of the book series: NATO ASI Series ((NSSA,volume 115))

Abstract

There have been various approaches to the classification of brain damage resulting from a non-missile head injury. One is that being used in this Symposium, namely primary and secondary. Primary damage occurs at the moment of injury and consists mainly of contusions and diffuse axonal injury, while secondary damage can be considered as a complication of the original injury and includes intracranial haematoma, brain damage secondary to raised intracranial pressure, shift and herniation of the brain, brain swelling, and hypoxic brain damage (Adams, Gennarelli, and Graham, 1982). Since it is now known as a result of early CT-scans and experimental studies (see below) that some types of so-called secondary brain damage, such as haematoma and swelling, may be present very soon after the injury, the distinction between primary and secondary damage is becoming somewhat blurred. There is therefore much to commend classifying brain damage resulting from a head injury as being focal or diffuse (Adams and Graham, 1984).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Adams JH, The neuropathology of head injuries, In: “Handbook of clinical neurology”, Vol. 23, Injuries of the brain and skull, Part 1, Vinken PJ, Bruyn GW, eds., American Elsevier, New York (1975).

    Google Scholar 

  • Adams JH, Gennarelli TA, Graham DI, Brain damage in non-missile head injury: Observations in man and subhuman primates, In: “Recent advances in neuropathology”, 2, Smith WT, Cavanagh JB, eds., Churchill Livingstone, Edinburgh (1982).

    Google Scholar 

  • Adams JH, Graham DI, Diffuse brain damage in non-missile head injury, In: “Recent advances in histopathology”, 12, Anthony PP, Mac Sween RNM, eds., Churchill Livingstone, Edinburgh (1984).

    Google Scholar 

  • Adams JH, Graham DI, Gennarelli TA, Neuropathology of acceleration-induced head injury in the subhuman primate, In: “Head injury: Basic and Clinical Aspects”, Grossmann RG, Gildenberg PL, eds., Raven Press, New York (1982).

    Google Scholar 

  • Adams JH, Graham DI, Gennarelli TA, Head injury in man and experimental animals — neuropathology, Acta Neurochirg Suppl. 32: 15 (1983).

    CAS  Google Scholar 

  • Adams JH, Graham DI Murray LS, Scott G, Diffuse axonal injury due to non-missile head injury in humans, Ann Neurol 12: 557 (1982).

    Article  CAS  Google Scholar 

  • Adams JH, Graham DI, Scott G, Parker LS, Doyle D, Brain damage in non-missile head injury, J Clin Pathol 33: 1132 (1980a).

    Article  CAS  Google Scholar 

  • Adams JH, Scott G, Parker LS, Graham DI, Doyle D, The contusion index: a quantitative approach to cerebral contusions in head injury, Neuropathol Appl Neurobiol 6: 319 (1980b).

    Article  CAS  Google Scholar 

  • Dawson SL, Hirsch CS, Lucas FV, Sebek BA, The contrecoup phenomenon: reappraisal of a classic problem, Human Pathol 11: 155 (1980).

    Article  CAS  Google Scholar 

  • Gennarelli TA, Head injury in man and experimental animals — clinical aspects, Acta Neurochirg Suppl. 32: 1 (1983).

    CAS  Google Scholar 

  • Gennarelli TA, Thibault LE, Adams JH, Graham DI, Thompson CJ, Marcincin RP, Diffuse axonal injury and traumatic coma in the primate, Ann Neurol 12: 564 (1982).

    Article  CAS  Google Scholar 

  • Graham DI, McLellan D, Adams JH, Doyle D, Kerr A, Murray LS, The neuropathology of severe disability after head injury, Acta Neurochirg Suppl. 32: 65 (1983).

    CAS  Google Scholar 

  • Gronwall D, Wrightson P, Delayed recovery of intellectual function after minor head injuries, Lancet 2: 605 (1974).

    Article  CAS  Google Scholar 

  • Hardman JM, The pathology of traumatic brain injuries, In: “Advances in neurology”, Vol. 22, Thompson RA, Green JR, eds., Raven Press, New York (1979).

    Google Scholar 

  • Jellinger K, Pathology and pathogenesis of apallic syndromes following closed head injuries, In: “The apallic syndrome”, Ore GD, Gerstenbrand F, Lucking CH, Peters G, Peters UH, eds., Springer Verlag, Berlin (1977).

    Google Scholar 

  • Lindenberg R, Freytag E, Morphology of cerebral contusions, Arch Pathol 63: 23 (1957).

    Google Scholar 

  • Lindenberg R, Freytag E, A mechanism of cerebral contusions: a pathologic-anatomic study, Arch Pathol 69: 440 (1960).

    CAS  Google Scholar 

  • Lindenberg R, Freytag E, Brain stem lesions of traumatic hyperextension of the head, Arch Pathol 90: 504 (1970).

    Google Scholar 

  • Oppenheimer DR, Microscopic lesions in the brain following head injury, J Neurol Neurosurg Psychiat 31: 229 (1968).

    Article  Google Scholar 

  • Peters G, Rothemund E, Neuropathology of the traumatic apallic syndrome, In: “The apallic syndrome”, Ore GD, Gerstenbrand F, Lucking CH, Peters G, Peters UH, eds., Springer Verlag, Berlin (1977).

    Chapter  Google Scholar 

  • Pilz P, Strohecker J, Grobovschek M, Survival after ponto-medullary tear, J Neurol Neurosurg Psychiat 45: 422 (1982).

    Article  CAS  Google Scholar 

  • Strich SJ, Diffuse degeneration of the cerebral white matter in severe dementia following head injury, J Neurol Neurosurg Psychiat 19: 163 (1956).

    Article  CAS  Google Scholar 

  • Strich SJ, Notes on the Marchi method for staining degenerating myelin in the peripheral and central nervous system, J Neurol Neurosurg. Psychiat 31: 110 (1968).

    Article  CAS  Google Scholar 

  • Tomlinson BE, Brain-stem lesions after severe head injury, In: “The pathology of trauma”, Sevitt S, Stoner HB, eds., J Clin Pathol 23, Supp1.4:154 (1970).

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1986 Plenum Press, New York

About this chapter

Cite this chapter

Adams, J.H., Graham, D.I., Gennarelli, T.A. (1986). Primary Brain Damage in Non-Missile Head Injury. In: Baethmann, A., Go, K.G., Unterberg, A. (eds) Mechanisms of Secondary Brain Damage. NATO ASI Series, vol 115. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5203-7_1

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-5203-7_1

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5205-1

  • Online ISBN: 978-1-4684-5203-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics