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Substantia Innominata — Cortical Cholinergic Pathway: Regulatory Afferents

  • P. L. Wood
  • P. McQuade
Part of the Advances in Behavioral Biology book series (ABBI, volume 30)

Abstract

The large forebrain neurons of the substantia innominata (SI) extensively innervate the ipsilateral cerebral cortex (2, 6). In addition, these neurons stain for acetylcholinesterase (7, 9, 13, 18) and lesions of the SI result in 50–80% decreases in cortical choline acetyltransferase (5, 7, 8). These data strongly support the cholinergic makeup of the substantia innominata-cholinergic pathway (SICP). In this report, we summarize our studies of the transynaptic regulation of the SICP, with particular focus on potential direct innervations of the cholinergic cell bodies in the SI. To this end, local injections of defined receptor agonists or antagonists into the SI have been compared with parenteral injections for their actions on cortical cholinergic function.

Keywords

Cholinergic Neuron Kainic Acid Parenteral Injection GABAergic Input Substantia Innominata 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • P. L. Wood
    • 1
  • P. McQuade
    • 2
  1. 1.Neuroscience Research, Pharmaceuticals DivisionCIBA-GEIGY CorporationSummitUSA
  2. 2.Research CentreDouglas HospitalVerdunCanada

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