Excitatory Amino Acid Influence on Striatal Cholinergic Transmission

  • B. Scatton
  • D. Fage
Part of the Advances in Behavioral Biology book series (ABBI, volume 30)


The corpus striatum contains a discrete population of cholinergic interneurons which represents about 1–2% of the total neostriatal neuronal population. The striatal cholinergic interneuron corresponds morphologically to the large aspiny neuron described by Kemp and Powell (7). These nerve cells appear to possess an important functional role in extrapyramidal motor function, and have been particularly implicated in the translation of alterations of nigro-striatal dopaminergic transmission into behavioral patterns (for review see Lloyd, 10).


Excitatory Amino Acid Cholinergic Neuron Excitatory Amino Acid Receptor Striatal Slice Cholinergic Interneuron 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Davies, J. and Watkins, J.C. (1977): Brain Res. 130: 364–368.CrossRefGoogle Scholar
  2. 2.
    Davies, J. and Watkins, J.C. (1981): In Glutamate as a Neurotransmitter (eds) G. DiChiara and G.L. Cessa, Raven Press, New York, pp. 275–284.Google Scholar
  3. 3.
    Euvrard, C., Javoy, F., Herbet, A. and Glowinski, J. (1977): Europ. J. Pharmacol. 41: 281–289.CrossRefGoogle Scholar
  4. 4.
    Fibiger, H.C. (1982): Brain Res. Reviews 4: 327–388.CrossRefGoogle Scholar
  5. 5.
    Hassler, R., Chung, J.W., Rinne, U. and Wagner, A. (1978): Exp. Brain Res. 31: 67–80.CrossRefGoogle Scholar
  6. 6.
    Jenner, P., Marsden, C.D. and Taylor, R.J. (1981): Brit. J. Pharmacol. 72: 570 P.Google Scholar
  7. 7.
    Kemp, J. and Powell, T.P.S. (1971): Phil. Trans. Roy. Soc. Lond. B. 262: 383–401.Google Scholar
  8. 8.
    Kerwin, R.W., Luscombe, G.P., Pycock, C.J. and Sverakova, K. (1980): Brit. J. Pharmacol. 68: 174 P.Google Scholar
  9. 9.
    Lehmann, J. and Scatton, B. (1982): Brain Res. 252: 77–89.CrossRefGoogle Scholar
  10. 10.
    Lloyd, K.G. (1978): In Essays in Neurochemistry and Neuropharmacology (eds) M.B.H. Youdim, W. Lovenberg, D.F. Sharman and J.R. Lagnado, Wiley, New York, pp. 129–207.Google Scholar
  11. 11.
    Lodge, D. and Anis, N.A. (1982): Europ. J. Pharmacol. 77: 203–204.CrossRefGoogle Scholar
  12. 12.
    McBean, G.J. and Roberts, J.P. (1981): Nature 291: 593–594.CrossRefGoogle Scholar
  13. 13.
    McGeer, P.L., McGeer, E.G., Scherer, U. and Singh, K. (1977): Brain Res. 128: 369–373.CrossRefGoogle Scholar
  14. 14.
    McGeer, E.G., McGeer, P.L. and Singh, K. (1978): Brain Res. 139: 381–383.CrossRefGoogle Scholar
  15. 15.
    Perkins, M.N., Stone, T.W., Collins, J.F. and Curry, K. (1981): Neurosci. Lett. 23: 333–336.CrossRefGoogle Scholar
  16. 16.
    Roberts, P.J. and Anderson,S.D. (1979): J. Neurochem. 32: 1539-1545.CrossRefGoogle Scholar
  17. 17.
    Scatton, B. and Bartholini, G. (1981): In Cholinergic Mechanisms (eds) G. Pepeu and H. Ladinsky, Plenum Publishing Corporation, pp. 771–780.Google Scholar
  18. 18.
    Scatton, B. and Lehmann, J. (1982): Nature 297: 422–424.CrossRefGoogle Scholar
  19. 19.
    Stone, T.W. (1979): Br. J. Pharmac. 67: 545–551.Google Scholar
  20. 20.
    Stone, T.W. and Perkins, M.N. (1981): Europ. J. Pharmacol. 72: 411–412.CrossRefGoogle Scholar
  21. 21.
    Watkins, J.C. (1981): In Glutamate: Transmitter in the Central Nervous System (eds) P.J. Roberts, J. Storm-Mathisen and G.A. Johnston, John Wiley, Chichester, U.K., pp. 1–24.Google Scholar
  22. 22.
    Watkins, J.C., Davies, J., Evans, R.H., Francis, A.A. and Jones, A.W. (1981): In Glutamate as a Neurotransmitter (eds) G.D. DiChiara and G.L. Cessa, Raven Press, New York, pp. 263–273.Google Scholar
  23. 23.
    Wood, P.L., Moroni, F., Cheney, D.L. and Costa, E. (1979): Neurosci. Lett. 12: 349–354.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • B. Scatton
    • 1
  • D. Fage
    • 1
  1. 1.Synthelabo-L.E.R.S.Biochemical Pharmacology GroupBagneuxFrance

Personalised recommendations