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Choline Uptake in the Hippocampus: Inhibition of Septal-Hippocampal Cholinergic Neurons by Intraventricular Barbiturates

  • J. A. Richter
Part of the Advances in Behavioral Biology book series (ABBI, volume 30)

Abstract

Simon et al. (15) first reported that in vivo administration of pentobarbital caused an inhibition of high-affinity, sodiumdependent choline uptake which was measured in vitro in hippocampal synaptosomes. This effect is believed to be related to a decrease in activity in the septal-hippocampal neurons. We have been interested in determining just where in the brain the drug acts to cause this effect and what behavioral consequences result from this particular effect of barbiturates.

Keywords

Lateral Ventricle Hypertonic Saline GABAergic Interneuron Cannula Guide Medial Septum 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • J. A. Richter
    • 1
  1. 1.Departments of Pharmacology and PsychiatryIndiana University School of MedicineIndianapolisUSA

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