Choline Uptake in the Hippocampus: Inhibition of Septal-Hippocampal Cholinergic Neurons by Intraventricular Barbiturates

  • J. A. Richter
Part of the Advances in Behavioral Biology book series (ABBI, volume 30)


Simon et al. (15) first reported that in vivo administration of pentobarbital caused an inhibition of high-affinity, sodiumdependent choline uptake which was measured in vitro in hippocampal synaptosomes. This effect is believed to be related to a decrease in activity in the septal-hippocampal neurons. We have been interested in determining just where in the brain the drug acts to cause this effect and what behavioral consequences result from this particular effect of barbiturates.


Lateral Ventricle Hypertonic Saline GABAergic Interneuron Cannula Guide Medial Septum 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    Brunello, N. and Cheney, D.L. (1981): J. Pharmacol. Exp. Therap. 219: 489–495.Google Scholar
  2. 2.
    Herz, A., Albus, K., Metys, J., Schubert, P. and Teschemacher, H. (1970): Neuropharmacology 9: 539–551.CrossRefGoogle Scholar
  3. 3.
    König,J.F.R. and Klippel, R.A. (1974): The Rat Brain. A Stereotaxic Atlas of the Forebrain and Lower Parts of the Brain Stem. Robert E. Krieger Pub. Co., Inc., Huntington, NY.Google Scholar
  4. 4.
    LoConte, G., Bartolini, L., Casamenti, F., Marconcini Pepeu, I. and Pepeu, G. (1982): Pharmacol. Biochem. and Behay. 17: 933–937.CrossRefGoogle Scholar
  5. 5.
    Lowry, O.H., Rosebrough, N.J., Farr, A.L. and Randall, R.J. (1951): J. Biol. Chem. 193: 265–295.Google Scholar
  6. 6.
    Miller, J.A. and Richter, J.A. (1984): Br. J. Pharmacol., in press.Google Scholar
  7. 7.
    Miller, J.A. and Richter, J.A. (1983): Soc. Neurosci. Abs. 9: 971.Google Scholar
  8. 8.
    Nicoll, R. (1978): In: Psychopharmacology: A Generation of Progress, (eds) M.A. Lipton, A. DiMascio and K.F. Killam, Raven Press, NY, pp. 1337–1348.Google Scholar
  9. 9.
    Olsen, R.W. (1981): J. Neurochem. 37: 1–13.CrossRefGoogle Scholar
  10. 10.
    Perry, E.K. and Perry,R.H. (1980): In: Biochemistry of Dementia (ed) P.J. Roberts, John Wiley and Sons, Ltd., London, pp. 135–183.Google Scholar
  11. 11.
    Perry, E.K., Tomlinson, B.E., Blessed, G., Bergmann, K., Gibson, P.H. and Perry, R.H. (1978): Brit. Med. J. 2: 1457–1459.CrossRefGoogle Scholar
  12. 12.
    Richter, J.A. and Gormley, J.M. (1982): J. Pharmacol. Exp. Therap. 222: 778–785.Google Scholar
  13. 13.
    Richter, J.A. and Holtman, J.R., Jr. (1982): Prog. Neurobiol. 18: 275–319.CrossRefGoogle Scholar
  14. 14.
    Richter, J.A., Gormley, J.M., Holtman, J.R., Jr., and Simon, J.R. (1982): J. Neurochem. 39: 1440–1445.CrossRefGoogle Scholar
  15. 15.
    Simon, J.R., Atweh, S. and Kuhar, M.J. (1976): J. Neurochem. 26: 909–922.CrossRefGoogle Scholar
  16. 16.
    Wood, P.L., Cheney, D.L. and Costa, E. (1979): Neuroscience 4: 1479–1484.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • J. A. Richter
    • 1
  1. 1.Departments of Pharmacology and PsychiatryIndiana University School of MedicineIndianapolisUSA

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