The Role of Glial Cells in Neuronal Acetylcholine Synthesis

Part of the Advances in Behavioral Biology book series (ABBI, volume 30)


Earlier reports have suggested that the choline (Ch) supply for acetylcholine (ACh) synthesis may originate from the blood (1), or be released (5), or synthesized de novo by different enzymes in the brain (9). There are no data, however, on the role of glial cells in neuronal ACh synthesis. Some years ago, Tuček (12) put forward the idea that Ch may be produced in the glial cells, from where it passes into the extracellular fluid, and is then taken up by the high-affinity (16) carrier system into the cholinergic axon terminals. On the basis of biochemical investigations, Ansell and Spanner (2) have suggested that glycerophosphocholine diesterase (GPCD: EC may be important in the release of Ch from the glial cells. It has also been noted that central neurons “fare better” in cultures when in contact with non-neuronal cells (13), and especially glial cells (11). Since neither the fate of the Ch released from the glial cells nor the role of the contact between glial cells and neurons has yet been elucidated, our aim was to investigate these phenomena.


Glial Cell Scan Electron Micrograph Cholinergic Neuron Plastic Layer ChAT Activity 
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  1. 1.
    Ansell, G.B. and Spanner, S. (1971): Biochem. J. 122: 741–750.Google Scholar
  2. 2.
    Ansell, G.B. and Spanner, S. (1981): In Cholinergic Mechanism (eds) G. Pepeu and H. Ladinsky, Plenum Press, New York, pp. 393403.Google Scholar
  3. 3.
    Booher, J. and Sensenbrenner, M. (1972): Neurobiology 2: 97–105.Google Scholar
  4. 4.
    Fonnum, F. (1975): J. Neurochem. 24: 407–409.CrossRefGoogle Scholar
  5. 5.
    Freeman, J.J. and Jenden, D.J. (1976): Life Sci. 19: 949–962.CrossRefGoogle Scholar
  6. 6.
    Hanin, I. and Jenden, D.J. (1969): Biochem. Pharmacol. 18: 837845.Google Scholar
  7. 7.
    Kilbinger, H. (1973): J. Neurochem. 21: 421–429.CrossRefGoogle Scholar
  8. 8.
    Marchbanks,R.M. andlsrafl,M.J. (1971): J. Neurochem. 18: 439448.Google Scholar
  9. 9.
    Mozzi, R. and Porcellati, G. (1979): FEBS Letters 100: 363–366.CrossRefGoogle Scholar
  10. 10.
    Pettman, B., Louis, J.C. and Sensenbrenner, M. (1979): Nature 281: 378–380.CrossRefGoogle Scholar
  11. 11.
    Touzet, N. and Sensenbrenner, M. (1978): Dey. Neurosci. 1: 159163.Google Scholar
  12. 12.
    Tucek, S. (1978): In Acetylcholine Synthesis in Neurons (eds) J. Wiley and Sons, New York.Google Scholar
  13. 13.
    Varon, S. and Saier, M. (1975): Exp. Neurol. 48: 135–162.CrossRefGoogle Scholar
  14. 14.
    Vyas, S. and Marchbanks, M.J. (1981): J. Neurochem. 37: 14671474.Google Scholar
  15. 15.
    Wong, T.Y., Hoffman, D., Dreyfus, H., Louis, J.C. and Massarelli, R. (1982): Neurosci. Lett. 29: 293–296.CrossRefGoogle Scholar
  16. 16.
    Yamamura, H.I. and Snyder, S.H. (1973): J. Neurochem. 21: 13551374.Google Scholar
  17. 17.
    Yamamura, H.I. and Snyder, S.H. (1974): Proc. Natl. Acad. Sci. (Wash.) 71: 1725–1729.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • P. Kasa
    • 1
  1. 1.Central Research LaboratoryMedical UniversitySzegedHungary

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