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Biochemical Effects of Lecithin Administration

  • R. S. Jope
Part of the Advances in Behavioral Biology book series (ABBI, volume 30)

Abstract

Lecithin is being administered in large doses to patients with Alzheimer’s Disease and other disorders involving impaired CNS cholinergic activity with the goal of stimulating the synthesis and release of acetylcholine. However, there are many questions concerning the biochemical effects of lecithin that still have to be examined. Three questions involving lecithin treatment are addressed in this report: 1) Are there any similarities between the effects of lecithin on blood choline levels in rats and human subjects? 2) What are the effects of chronic versus acute treatment with lecithin on the concentrations of choline and acetylcholine? 3) Does lecithin have significant biochemical effects on metabolic processes besides those involving choline utilization? None of these questions can be answered adequately at this time, but recent results, described in this chapter, should help to formulate further research projects aimed at obtaining a more comprehensive understanding of the metabolic effects of the administration of large doses of lecithin.

Keywords

Cholinergic Activity Choline Level Choline Concentration Free Choline Plasma Choline 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Brunello, N., Cheney, D.L. and Costa, E. (1982): Neurochem. 38: 1160–1163.CrossRefGoogle Scholar
  2. 2.
    Eckernäs, S.A., Sahlstrüm, L. and Aquilonius, S.M. (1977): Acta Physiol. Scand. 101: 404–410.CrossRefGoogle Scholar
  3. 3.
    Folch, J., Lees, M. and Sloan-Stanley, G.H. (1957): J. Biol. Chem. 226: 497–508.Google Scholar
  4. 4.
    Friedman, E., Sherman, K.A., Ferris, S.H., Reisberg, B., Bartus, R.T. and Schneck, M.K. (1981): New Engl. J. Med. 304: 1490–1491, 1981.CrossRefGoogle Scholar
  5. 5.
    Hirsch, M.J., Growdon,J.H. and Wurtman, R.J. (1978): Metabolism 27: 953–960.CrossRefGoogle Scholar
  6. 6.
    Jope, R.S. (1982): J. Pharmacol. Exp. Therap. 220: 322–328.Google Scholar
  7. 7.
    Jope, R.S. and Jenden, D.J. (1979): J. Neurosci. Res. 4:69–82.CrossRefGoogle Scholar
  8. 8.
    Jope, R.S., Jenden, D.J., Ehrlich, B.E. and Diamond,J.M. (1978): New Engl. J. Med. 299: 833–834.Google Scholar
  9. 9.
    Jope, R.S., Jenden, D.J., Ehrlich, B.E., Diamond, J.M. and Gosenfeld, L.F. (1980): Proc. Natl. Acad. Sci. ( USA ) 77: 6144–6146.CrossRefGoogle Scholar
  10. 10.
    Jope, R.S., Domino, E.F., Mathews, B.N., Sitaram, N., Jenden, D.J. and Ortiz, A. (1982): Clin. Pharmacol. Therap. 31: 483–487.CrossRefGoogle Scholar
  11. 11.
    Jope, R.S., Jenden, D.J., Subramanian, C.S., Dhopeshwarker, G.A. and Duncan, J. (1984): Biochem. Pharmacol. 33 (5): 793–798.CrossRefGoogle Scholar
  12. 12.
    London, E.D. and Coyle, J.T. (1978): Biochem. Pharmacol. 27: 2962–2965.CrossRefGoogle Scholar
  13. 13.
    Menon, N.K. and Dhopeshwarker, G.A. (1980): In: Progress in Lipid Research (Ed) R.T. Holman, pp. 129–138, Pergamon Press, Oxford, England.Google Scholar
  14. 14.
    Mervis, R.F. and Bartus, R.T. (1981): J. Neuropathol. Exp. Neurol. 40: 313–321.Google Scholar
  15. 15.
    Millington, W.R. and Wurtman, R.J. (1982): J. Neurochem. 38: 1748–1752.CrossRefGoogle Scholar
  16. 16.
    Schmidt, D.E. and Wecker, L. (1981): Neuropharmacol. 20: 535–539.CrossRefGoogle Scholar
  17. 17.
    Sherman, K.A., Zigmond, M.J. and Hanin, I. (1978): Life Sci. 23: 1863–1870.CrossRefGoogle Scholar
  18. 18.
    Wecker, L. and Dettbarn, W.D. (1979): J. Neurochem. 32: 961–967CrossRefGoogle Scholar
  19. 19.
    Wecker, L., Dettbarn, W.D. and Schmidt, D.E. (1978): Science 199: 86–87.CrossRefGoogle Scholar
  20. 20.
    Zeisel, S.H., Wishnok, J.S. and Blusztajn, J.K. (1983): J. Pharmacol. Exp. Ther. 225: 320–324.Google Scholar

Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • R. S. Jope
    • 1
  1. 1.Department of Pharmacology and Neuroscience ProgramUniversity of Alabama in BirminghamBirminghamUSA

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