Structural Gene Mutations Affecting Acetylcholinesterase and Choline Acetyltransferase Perturb Behavior and Development in a Simple Invertebrate

  • R. L. Russell
  • J. B. Rand
Part of the Advances in Behavioral Biology book series (ABBI, volume 30)


For cholinergic transmission, as for many other processes of biological interest, a genetic approach can sometimes offer advantages complementary to those of other approaches. Most notable amongst these advantages is the ability, by mutation, to alter specifically the products of individual genes which may be involved. Sometimes such mutations can serve to pinpoint the roles of already identified gene products, and in other cases mutations can serve to point out the unsuspected involvement of other gene products, whose nature remains to be worked out.


Ventral Nerve Cord Cholinergic Transmission Cholinergic Synapse Severe Mutation Choline Acetyl Transferase 
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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • R. L. Russell
    • 1
    • 2
  • J. B. Rand
    • 1
  1. 1.Department of Biological SciencesUniversity of PittsburghPittsburghUSA
  2. 2.Department of PsychiatryUniversity of PittsburghPittsburghUSA

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