Acetylcholine Turnover in Mouse Brain: Influence of Cholinesterase Inhibitors

  • B. Karlén
  • G. Lundgren
  • J. Lundin
  • B. Holmstedt
Part of the Advances in Behavioral Biology book series (ABBI, volume 30)


Evidence has been presented to indicate that in neurons the concentrations of neurotransmitters are maintained at constant levels although the rates of transmitter metabolism are changing (10, 13). However, in cholinergic neurons there is evidence to show that concentrations of acetylcholine (ACh) are accompanied by changes in the rate of metabolism of this transmitter (11).


Turnover Rate Mass Fragmentography Propionyl Chloride Fractional Rate Constant Focus Microwave Irradiation 
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  1. 1.
    Costa, E. (1970): In Advances in Biochemical Psychopharmacology. Vol. 2 (eds) E. Costa and E. Giacobini, Raven Press, New York, pp. 162–204.Google Scholar
  2. 2.
    Fleischer, J.H. and Harris, L.W. (1965): Biochem. Pharmacol. 14: 641–650.CrossRefGoogle Scholar
  3. 3.
    Harris, L.W., Fleischer, J.H., Clark, J. and Cliff, W.J. (1966): Science 154: 404–407.CrossRefGoogle Scholar
  4. 4.
    Karlén, B., Lundgren, G., Nordgren, I. and Holmstedt, B. (1974): In Choline and Acetylcholine, Handbook of Chemical Assay Methods (ed) I. Hanin, Raven Press, New York, pp. 163–179.Google Scholar
  5. 5.
    Karlén, B., Lundgren, G., Lundin, J. and Holmstedt, B. (1977): Life Sci. 20: 1651–1655.CrossRefGoogle Scholar
  6. 6.
    Karlén, B., Lundgren, G., Miyata, T., Lundin, J. and Holmstedt, B. (1978): In Cholinergic Mechanisms and Psychopharmacology (ed) D.J. Jenden, Plenum Publishing Co., New York, pp. 643–655.Google Scholar
  7. 7.
    Karlén, B., Lundgren, G., Lundin, J. and Holmstedt, B. (1979): Naunyn-Schmiedeberg’s Arch. Pharmacol. 308: 61–65.Google Scholar
  8. 8.
    Karlén, B., Lundgren, G., Lundin, J. and Holmstedt, B. (1982): Biochem. Pharmacol. 31: 2867–2872.CrossRefGoogle Scholar
  9. 9.
    Lundgren, G., Karlén, B. and Holmstedt, B. (1977): Biochem. Pharmacol. 26: 1607–1612.CrossRefGoogle Scholar
  10. 10.
    Neff, N.H. and Costa, E. (1966): Excerpta. Med. Int. Congr. Ser. 122: 23–34.Google Scholar
  11. 11.
    Schuberth, J., Sparf, B. and Sundwall, A. (1969): J. Neurochem. 16: 695–700.CrossRefGoogle Scholar
  12. 12.
    Sidell, F.R. and Groff, W.A. (1974): Tox. Appl. Pharmacol. 27: 241–252.CrossRefGoogle Scholar
  13. 13.
    Sedvall, G.C. and Kopin, I.J. (1967): Life Sci. 6: 45–51.CrossRefGoogle Scholar
  14. 14.
    Zilversmit, D.B. (1960): Am. J. Med. 29: 832–848.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • B. Karlén
    • 2
  • G. Lundgren
    • 1
  • J. Lundin
    • 1
  • B. Holmstedt
    • 1
  1. 1.Department of Toxicology The Swedish Medical Research CouncilKarolinska InstitutetStockholmSweden
  2. 2.Research DepartmentKabiVitrum ABStockholmSweden

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